Aikawa, Shin Win Department of Medicine 2020 Innovation Evergreen Fund Award

Elena Aikawa, MD, PhD, director of the Heart Valve Translational Research Program in the Division of Cardiovascular Medicine, and Su Ryon Shin, PhD, of the Division of Engineering in Medicine, received the Brigham Department of Medicine ’s 2020 Innova
Source: BWH News - Category: Hospital Management Source Type: news

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Resveratrol is a bioactive phenol shown to reduce T cell activation through inhibition of mTOR pathways. Recent studies show cell-mediated immune reactions cause structural valve deterioration (SVD) in xenograft valves. Thus, tissue-engineered heart valves (TEHV) with decellularized bovine pericardium have been developed to reduce the immune response. Our study examines whether resveratrol could further decrease the immune rejection against xenogenic bovine pericardium.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1197) Source Type: research
Tissue engineered heart valves have been created in order to reduce the xenoreactive immune response thought to be responsible for structural valve deterioration (SVD) of bioprosthetic heart valve replacements. Our study looks to elucidate whether tissue engineering a commercially available porcine extracellular matrix will significantly attenuate the xenoreactive immune response when compared to the wild-type matrix.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1195) Source Type: research
Biofilms usually occur on or within medical devices such as mechanical heart valves, prosthetic joints, peritoneal dialysis catheters, contact lenses, central venous catheters, pacemakers and urinary catheters. The presence of biofilms can be seen in different diseases like endocarditis, otitis, cystic fibrosis, periodontitis, osteomyelitis and chronic wounds. Toxin–antitoxin systems are reported to respond to stresses that are also found in the host. Some toxins of toxin–antitoxin systems modules have been proposed as potential weapons used by bacteria to act on host targets. In this review, we focus on the mo...
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: BACTERIOLOGY Source Type: research
The molecular basis of the pathogenesis of the opportunistic invasive infections caused by isolates of the Gemella genus remains largely unknown. Moreover, inconsistencies in the current species assignation were detected after genome-level comparison of 16 public Gemella isolates. A literature search detected that, between the two most pathogenic species, Gemella morbillorum causes about twice the number of cases compared to Gemella haemolysans. These two species shared their mean diseases – sepsis and endocarditis – but differed in causing other syndromes. A number of well-known virulence factors were harbored...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
(American College of Cardiology) Patients undergoing transcatheter aortic valve replacement (TAVR) fared equally well compared with those undergoing open heart valve replacement surgery in terms of the combined risk of death, stroke or rehospitalization at two years, the primary endpoint of the PARTNER 3 trial being presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(American College of Cardiology) Patients who underwent transcatheter aortic valve replacement (TAVR) did not have a higher rate of death at one year compared with those who had their heart valve replaced via open-heart surgery, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
RARITAN, NJ, March 28, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced the VOYAGER PAD study met its primary efficacy and principal safety endpoints, demonstrating the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily) plus aspirin (100 mg once daily) was superior to aspirin alone in reducing the risk of major adverse limb and cardiovascular (CV) events by 15 percent in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization, with similar rates of TIMI[1] major bleeding. VOYAGER PAD is the only study to show a significant benefit...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Abstract Ischemic heart disease is a predominant cause of death worldwide. The loss or death of cardiomyocytes due to restricted blood flow often results in a cardiac injury. These injured cardiomyocytes are replaced by myofibroblasts that preserve structural integrity. However, the depleted cardiomyocytes lead to cardiac dysfunction such as pathological cardiac dilation, reduced cardiac contraction and fibrosis. Repair and regeneration of myocardium are the best possible therapy for the end-stage heart failure patients because the current therapies that can help restore the lost cardiomyocytes are limited to hear...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
CONCLUSIONS: Although VHD did not significantly affect thromboembolism or mortality, it affected cardiac events depending on type, with aortic valve diseases having higher risk, in Japanese patients with AF. PMID: 32213725 [PubMed - as supplied by publisher]
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
ConclusionIn children, the results of mitral valve replacement were found to be inferior to those of mitral valve repair. The reoperation rates are similar in patients undergoing initial repair or replacement, which favors repair as an option. In developing world, rheumatic mitral valve disease is more prevalent where adequate facilities for monitoring of prosthetic valve function and management of anticoagulation therapy are not easily available. Valve repair therefore should be the primary goal.
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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