Subjects at risk of Parkinson ’s disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study

AbstractIntroductionThe present study aimed to survey the prevalence of prodromal symptoms of Parkinson ’s disease (PD) in Japanese health checkup examinees, for identifying at-risk subjects.MethodsWe conducted a questionnaire survey of annual health checkup examinees without neurological symptoms using the following self-reported questionnaires: Japanese version of the Scale for Outcomes in Parkinson ’s disease for Autonomic Symptoms (SCOPA-AUT); Self-administered Odor Question (SAOQ); REM Sleep Behavior Disorder Screening Scale (RBDSQ); Beck Depression Inventory-Second Edition (BDI-II); Epworth Sleepiness Scale (ESS); and Physical Activity Scale for the Elderly (PASE). The presence of prodrom al symptoms was determined using the 90th percentile threshold of each questionnaire. Subjects ≥ 50 years of age with ≥ 2 core prodromal symptoms (dysautonomia, hyposmia, and RBD), were classified as at risk.ResultsBetween March 2017 and March 2018, 4,953 participants sufficiently answered the questionnaires. Among 2,726 subjects  ≥ 50 years of age, 155 were classified as at risk. These subjects had worse values of BDI-II (12.0 ± 8.3 vs. 4.4 ± 3.8,p 
Source: Journal of Neurology - Category: Neurology Source Type: research

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Publication date: Available online 5 April 2020Source: Aggression and Violent BehaviorAuthor(s): Alison Datoc, Kirsten Horne, Charles Golden
Source: Aggression and Violent Behavior - Category: Psychiatry & Psychology Source Type: research
Study Design. A retrospective study. Objective. To assess the long-term results of zero-profile spacer for 3-level anterior cervical discectomy and fusion (ACDF). Summary of Background Data. Although widely used, there are still controversies about the long-term results of zero-profile spacer, especially in multilevel cases. Methods. Cases received 3-level ACDF for cervical spondylotic myelopathy (CSM) using either zero-profile spacer (nā€Š=ā€Š27) (ZP Group), or plate and cages (nā€Š=ā€Š34) (PC Group), and with 5-year follow-up were reviewed. Neurological function and life quality were assessed by modified Japan...
Source: Spine - Category: Orthopaedics Tags: CERVICAL SPINE Source Type: research
Conclusion. The results of this study yield further support for the importance of rapid functional improvements during a PT episode of care. In addition, patients demonstrated roughly two-thirds of their improvement in the first 40% of visits regardless of their symptom duration. This study may help clinicians identify a need to modify a plan of care if insufficient early improvement is observed. Level of Evidence: 3
Source: Spine - Category: Orthopaedics Tags: HEALTH SERVICES RESEARCH Source Type: research
Study Design. A prospective cross-sectional study. Objective. To evaluate the prevalence of sacroiliac joint dysfunction in patients with lumbar disc hernia and examine the variations in clinical parameters cause by this combination. Summary of Background Data. Although one of the many agents leading to lumbar pain is sacroiliac dysfunction, little progress has still been made to evaluate mechanical pain from sacroiliac joint dysfunction within the context of differential diagnosis of lumbar pain. Methods. Two hundred thirty-four patients already diagnosed with lumbar disc hernia were included in the study. Duri...
Source: Spine - Category: Orthopaedics Tags: HEALTH SERVICES RESEARCH Source Type: research
Living with type 1 diabetes and having trouble sleeping? DiabetesMine has some ideas to help.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
There are a number of things that can increase the risk of dementia: age, of course, as well as certain genetic profiles and behaviors such as smoking and drinking. Some of the same things that contribute to heart disease, such as high cholesterol levels and the build up of plaques in the blood vessels, can also boost the chances of developing dementia. And in a large study published in JAMA Internal Medicine conducted in the UK, researchers report another possible factor: a group of drugs known as anticholinergics. These include prescription medications for treating depression, pulmonary disease, and Parkinson’s, as...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Brain Dementia Drugs Source Type: news
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions Self-reported frequent sleep disturbance in middle-aged men may relate to the development of dementia in later life. Having an APOE 4 genotype did not affect the relationship.
Source: Journal of Epidemiology and Community Health - Category: Epidemiology Authors: Tags: Smoking and tobacco, Alcohol, Health education, Health promotion, Smoking Research reports Source Type: research
Discussion Caffeine is a natural alkaloid found in more than 60 plants and is the most, or one of the most, ingested bioactive substances in the world. It is ingested most commonly in beverages (coffee, tea, soft drinks, energy drinks, caffeinated water or alcohol) but is also found in foods, medications, dietary supplements and over-the-counter stimulants. In the US coffee is the major source for adults. The concentration of caffeine depends on many factors such as the coffee species, agricultural practices, drying and storage of the beans, and the roasting, grinding and brewing of the coffee. In the US children ingest ca...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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