Decoding Bone Marrow Fibrosis in Myelodysplastic Syndromes

We examined the relationship between bone marrow fibrosis (BMF) in myelodysplastic syndromes and survival outcomes, and somatic gene mutations in the setting of BMF. Grade 3 BMF was associated with reduced overall survival; however, BMF grade did not affect response to hypomethylating agent or lenalidomide treatment. Complex karyotype, higher bone marrow myeloblasts, lower platelets, and higher rate of elevated lactate dehydrogenase were more often observed in patients with severe BMF. TP53  mutation and SETBP1 were more frequent in patients with grade 3 BMF.

Source: Clinical Lymphoma, Myeloma and Leukemia - January 13, 2020 Category: Hematology Authors: Megan Melody, Najla Al Ali, Ling Zhang, Hanadi Ramadan, Eric Padron, David Sallman, Kendra Sweet, Jeffrey Lancet, Alan List, John M. Bennett, Rami Komrokji Tags: Original Study Source Type: research