Hypothalamic POMC Deficiency Increases Circulating Adiponectin Despite Obesity

ConclusionIn summary, we provide the first evidence that despite obesity, the ArcPomc-/- mouse model has high circulating adiponectin levels, which revealed that increased fat mass is not necessarily correlated with hypoadiponectinemia. Our investigation also uncovered a previously unknown physiological pathway connecting POMC neurons via the sympathetic nervous system to circulating adiponectin, thereby shedding light on the biological regulation of adiponectin.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research