Rationale and design of two randomized sham-controlled trials of catheter-based renal denervation in subjects with uncontrolled hypertension in the absence (SPYRAL HTN-OFF MED Pivotal) and presence (SPYRAL HTN-ON MED Expansion) of antihypertensive medications: a novel approach using Bayesian design

ConclusionsThe Bayesian paradigm represents a novel and promising approach in device-based hypertension trials.Clinical trial registrationURL:https://www.clinicaltrials.gov. Unique identifier: NCT02439749 (SPYRAL HTN-OFF MED Pivotal) and NCT02439775 (SPYRAL HTN-ON MED Expansion).

http://link.springer.com/10.1007/s00392-020-01595-z

Source: Clinical Research in Cardiology - February 6, 2020 Category: Cardiology Source Type: research