Manipulating microRNAs for the Treatment of Malignant Pleural Mesothelioma: Past, Present and Future

microRNAs (miRNAs) are an important class of non-coding RNA that post-transcriptionally regulate the expression of most protein-coding genes. Their aberrant expression in tumors contributes to each of the hallmarks of cancer. In malignant pleural mesothelioma (MPM), in common with other tumor types, changes in miRNA expression are characterized by a global downregulation, although elevated levels of some miRNAs are also found. While an increasing number of miRNAs exhibit altered expression in MPM, relatively few have been functionally characterized. Of a growing number with tumor suppressor activity in vitro, miR-16, miR-193a, and miR-215 were also shown to have tumor suppressor activity in vivo. In the case of miR-16, the significant inhibitory effects on tumor growth following targeted delivery of miR-16-based mimics in a xenograft model was the basis for a successful phase I clinical trial. More recently overexpressed miRNAs with oncogenic activity have been described. Many of these changes in miRNA expression are related to the characteristic loss of tumor suppressor pathways in MPM tumors. In this review we will highlight the studies providing evidence for therapeutic effects of modulating microRNA levels in MPM, and discuss these results in the context of emerging approaches to miRNA-based therapy.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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The Florida Legislature has passed a bill designed to better protect its firefighters from cancer-causing contaminants, including toxic asbestos. By approving the legislation, Florida joined a growing number of states that have passed laws in recent years to help firefighters combat occupational hazards they face every day. The Firefighter Cancer Decontamination Equipment Grant Program in Florida will provide funding for departments to procure supplies, equipment and add additional training that should reduce exposure to hazardous pollutants. It includes all fire departments across the state, from large municipal entities...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Conditions:   Thoracic Cancer;   Non-small Cell Lung Cancer;   Small-cell Lung Cancer;   Pleural Mesothelioma Intervention:   Other: eRAPID online symptom monitoring in lung cancer Sponsors:   University of Leeds;   The Leeds Teaching Hospitals NHS Trust;   Iqvia Pty Ltd Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
As the U.S. comes to grips with the challenges of the COVID-19 pandemic, mesothelioma cancer survivors face additional hurdles, including difficulty receiving care. Patients currently undergoing treatment for cancer and those who are immunocompromised are at greater risk of serious health issues if they contract COVID-19, according to the Centers for Disease Control and Prevention. “Cancer patients are a high-risk group and should be extra vigilant in terms of isolation precautions. They should follow the medical authorities’ instructions,” Dr. Ory Wiesel, a thoracic surgeon at Maimonides Medical Center ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Malignant mesothelioma (MM), especially its more frequent form, malignant pleural mesothelioma (MPM), is a devastating thoracic cancer with limited therapeutic options. Recently, clinical trials that used immunotherapy strategies have yielded promising results, but the benefits are restricted to a limited number of patients. To develop new therapeutic strategies and define predictors of treatment response to existing therapy, better knowledge of the cellular and molecular mechanisms of MM tumors and sound preclinical models are needed. This review aims to provide an overview of our present knowledge and issues on both subj...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Raw asbestos imported to the United States dropped significantly in 2019, according to the recently released U.S. Geological Survey Mineral Commodity Summaries report. The U.S. imported an estimated 100 metric tons of asbestos last year. It’s the smallest amount since records were first kept in 1910, long before the mineral became a major part of the construction industry in America. That number is in sharp contrast to the 681 metric tons imported in 2018. All imported asbestos went to the chloralkali industry — for the second consecutive year — to use in the manufacturing of semipermeable diaphragms for ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Conditions:   Lung Cancer;   Head and Neck Cancer;   Bladder Cancer;   Esophageal Cancer;   Mesothelioma Interventions:   Biological: S-488210;   Biological: S-488211 Sponsor:   Shionogi Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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