Exosomal Sonic Hedgehog derived from cancer ‐associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma

Exosomal Sonic Hedgehog derived from cancer ‐associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma and this effect can be partly neutralized by the inhibitor of the Hedgehog signaling pathway. AbstractEsophageal squamous cell carcinoma (ESCC) is one of the most common and aggressive malignancies in China. Cancer ‐associated fibroblasts (CAFs) can actively communicate with and stimulate tumor cells, thereby contributing to the development and progression of tumors. Yet, whether CAFs‐derived exosomes have a role in the progression of ESCC is largely unknown. Here, we find that Sonic Hedgehog (SHH) is high ly expressed in CAFs lysis solution, conditioned medium of cultured CAFs (CAF‐CM) and CAFs‐derived exosomes, and esophageal cancer cell lines educated by CAF‐CM and CAFs‐derived exosomes can improve their growth and migration abilities in vitro and in vivo. Besides, those effects can be part ly neutralized by cyclopamine, inhibitor of the Hedgehog signaling pathway. Thus, our research elucidates the crucial role of CAFs‐derived exosomes in the growth and progression of ESCC, and may open up new avenues in the treatment of ESCC.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Diagnostic Pathology - Category: Pathology Authors: Tags: Research Source Type: research
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Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
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Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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Source: Cancer Biotherapy and Radiopharmaceuticals - Category: Cancer & Oncology Authors: Source Type: research
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