Information growth for sequential monitoring of clinical trials with a stepped wedge cluster randomized design and unknown intracluster correlation.

CONCLUSION: Taking the study design into account and using either an estimate of the intracluster correlation from the ongoing study or other data in the same clusters should allow for easy implementation of group sequential methods in future stepped wedge designs.
PMID: 32026713 [PubMed - as supplied by publisher]

Source: Clinical Trials - February 5, 2020 Category: Research Authors: Brown SP, Shoben AB Tags: Clin Trials Source Type: research