Novel Polymethoxylated Chalcones as potential compounds against KRAS-Mutant Colorectal Cancers.

CONCLUSION: Compounds 3 and 14 represent potent and selective leads for KRAS-mutant CRC cells, thus, further in vitro and in vivo studies are necessary to confirm their effect on KRAS-mutant CRCs.
PMID: 32026770 [PubMed - as supplied by publisher]

Source: Current Pharmaceutical Design - February 4, 2020 Category: Drugs & Pharmacology Authors: Mahmoud A, Elkhalifa D, Alali F, Al Moustafa AE, Khalil A Tags: Curr Pharm Des Source Type: research