Combination therapy with radiation and PARP inhibition enhances responsiveness to anti-PD-1 therapy in colorectal tumor models

The majority of colorectal cancers are resistant to cancer immune-checkpoint inhibitors. Ionizing radiation (IR) and several radiosensitizers, including PARP inhibitors, can enhance responsiveness to immune checkpoint inhibitors by potentially complementary mechanisms of action. We assessed the ability of radiation and PARP-inhibition to induce pro-immunogenic changes in tumor cells and enhance their in vivo responsiveness to anti-PD-1 antibodies.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research