Development of a Cardiovascular Disease Risk Prediction Model Using the Suita Study, a Population-Based Prospective Cohort Study in Japan.
CONCLUSIONS: The Suita CVD risk model is feasible to use and improves predictability of the incidence of CVD relative to the FRS model in Japan. PMID: 32023562 [PubMed - as supplied by publisher]
Publication date: 15 November 2020Source: Life Sciences, Volume 261Author(s): Yuan Zhang, Hui Jiang, Shengqian Dou, Bin Zhang, Xia Qi, Jing Li, Qingjun Zhou, Weina Li, Chen Chen, Qun Wang, Lixin Xie
Discussion Syphilis is caused by the spirochete Treponema pallidum. It is a very old disease that despite understanding the organism and readily available treatment, still causes disease. Syphilis is transmitted sexually. According to the Centers for Disease Control, “[i]n 2018, a total of 35,063 cases of [Primary and Secondary] syphilis were reported in the United States, yielding a rate of 10.8 cases per 100,000 population …. This rate represents a 14.9% increase compared with 2017 (9.4 cases per 100,000 population), and a 71.4% increase compared with 2014 (6.3 cases per 100,000 population).” The incre...
HEART attack symptoms include difficulty breathing, chest pain, and an overwhelming feeling of anxiety. But you could also be at risk of a deadly myocardial infarction and heart disease symptoms if you develop this sign on your skin. Has your skin changed colour?
Nusinersen can treat patients with spinal muscular atrophy by modulating alternate splicing of the SMN2 gene and increasing survival of motor neuron protein levels. Since the approval of nusinersen in Japan in 2017, we have evaluated such patients to understand the changes in the clinical course after completed treatment. Currently, the factors correlating with good and poor responses to nusinersen treatment remain unclear. We retrospectively assessed the clinical outcomes of our treated cohort, in relevance to the level of muscle damage semiquantified by muscle MRI performed before the treatment.
A subgroup of autophagic vacuolar myopathies (AVMs) is characterized by unusual autophagic vacuoles with sarcolemmal features (AVSFs) and includes Danon disease and X-linked myopathy with excessive autophagy (XMEA). We suggest referring to this subgroup as ‘AVSF myopathy’ as a new clinical entity. However, the features of AVSF myopathy have not been well established. Therefore, to evaluate the clinical features, we reviewed the clinical histories, muscle specimens, and genetic analyses of Japanese patients with AVSF myopathy.
Malignant hyperthermia (MH) and Exertional Heat Stroke (EHS) present hypermetabolic states leading to rhabdomyolysis and muscle rigidity with progressive hyperthermia; MH is triggered by volatile inhaled anesthetics, while EHS is triggered by exercise in hot/humid environment. Given the similarity of clinical features and the fact that a portion of EHS cases were diagnosed as MH susceptible by the in vitro contracture test, MH and EHS are believed to share common etiology. Mutations in RYR1 and CACNA1S have been found to be associated with MH; however the genetic cause remains to be identified in approximately 30% of MH cases.
We examined the influence of transportation noise exposure over a 5-y period (1994–1998) on incident diabetes cases in a population-based prospective cohort study (n=380,738) of metropolitan Vancouver (BC) residents who were 45–85 y old, with 4-y of follow-up (1999–2002). Annual average transportation noise (Lden), air pollution [black carbon, particulate matter with aerodynamic diameter 10% of the population was of South Asian ethnicity, and nearly one-half of the sample lived in neighborhoods where>10% of the population was of Chinese ethnicity. All covariates were significantly associated with all o...
Miramontes JP, Mata P, SAFEHEART Investigators Abstract OBJECTIVE: Heterozygous familial hypercholesterolemia (FH) is the most common premature atherosclerotic cardiovascular disease (ASCVD)-related monogenic disorder, and it is associated with ischemic heart disease. There is limited information whether FH increases the risk of peripheral arterial and cerebrovascular disease. Our aim was to analyze ASCVD prevalence and characteristics in different arterial territories in a large FH population, to compare them with an unaffected control population and to determine which factors are associated to ASCVD. APPROA...