SF3B1 Mutation but Not Ring Sideroblasts Identifies a Specific Group of Myelodysplastic Syndrome –Refractory Cytopenia With Multilineage Dysplasia

To investigate the clinical implications of SF3B1 and ring sideroblasts in myelodysplastic syndrome –refractory cytopenia with multilineage dysplasia (MDS-RCMD), 238 consecutive MDS-RCMD patients were studied. SF3B1 mutation in MDS-RCMD patients identified a homogenous phenotype characterized by homogeneous hematologic features, including a high prevalence of erythroid dysplasia and a high propo rtion of ring sideroblasts, prolonged survival, and reduced leukemic transformation.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research