Threonine phosphorylation of I κBζ mediates inhibition of selective proinflammatory target genes
Transcription factors of the NF- κB family play a crucial role for immune responses by activating the expression of chemokines, cytokines and antimicrobial peptides involved in pathogen clearance. IκBζ, an atypical nuclear IκB protein and selective coactivator of particular NF-κB target genes, has recently been identified as a n essential regulator for skin immunity. In the present study, we discovered that IκBζ is strongly induced in keratinocytes sensing the fungal glucan zymosan A and that IκBζ is essential for the optimal expression of proinflammatory genes, such as IL6, CXCL5, IL1B or S100A9.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Paula Grondona, Philip Bucher, Anja Schmitt, Caroline Sch önfeld, Barbara Streibl, Anne Müller, Frank Essmann, Sabrina Liberatori, Shabaz Mohammed, André Hennig, Daniela Kramer, Klaus Schulze-Osthoff, Stephan Hailfinger Tags: Original Article Source Type: research