Gliadin-induced ex vivo T cell response in dermatitis herpetiformis: A predictor of clinical relapse on gluten challenge?

Dermatitis herpetiformis (DH), an itchy blistering skin condition, is considered an extraintestinal manifestation of celiac disease. Both manifestations are driven by the ingestion of dietary gluten, which induces an inflammatory response hallmarked by B and T cell activation (Collin et al., 2017; du Pr é and Sollid 2015). In celiac disease, the gluten-induced T cell response has been assessed by various means, including an oral three-day wheat challenge coupled with an interferon-γ (IFN-γ) enzyme-linked immunospot (ELISpot) assay (Anderson et al., 2000; Tye-Din et al., 2010a; Camarca et al., 20 12; Hardy et al., 2015).

Source: Journal of Investigative Dermatology - February 5, 2020 Category: Dermatology Authors: Suvi Kalliokoski, Eriika Mansikka, Andrea de Kauwe, Heini Huhtala, P äivi Saavalainen, Kalle Kurppa, Kaisa Hervonen, Timo Reunala, Katri Kaukinen, Teea Salmi, Katri Lindfors Tags: Letters to the Editor Source Type: research