Targeting vascular smooth muscle cell dysfunction with xanthine derivative KMUP-3 inhibits abdominal aortic aneurysm in mice

Inflammation, oxidative stress, matrix degradation, medial calcification and vascular smooth muscle cell (VSMC) loss are prominent features in abdominal aortic aneurysm (AAA). VSMC phenotypic switch to a proinflammatory state and VSMC apoptosis could be targetable mechanisms implicated in the pathogenesis of AAA formation. Herein, we investigated the hypothesis that a xanthine derivative (KMUP-3) might suppress AAA through inhibition of VSMC phenotypic switch and apoptosis.

Source: Atherosclerosis - February 5, 2020 Category: Cardiology Authors: Chao-Han Lai, Ching-Wen Chang, Fang-Tzu Lee, Cheng-Hsiang Kuo, Jong-Hau Hsu, Chung-Pin Liu, Hua-Lin Wu, Jwu-Lai Yeh Source Type: research