Pharmacokinetic/pharmacodynamic relationship of therapeutic monoclonal antibodies used in oncology: Part 1, monoclonal antibodies, antibody-drug conjugates  and bispecific T-cell engagers

More than 25 therapeutic monoclonal antibodies (mAbs) used in oncology have been approved since 1997. Their nature has been largely modified through the last 20 years, from the chimeric IgG1 rituximab with pharmacokinetic parameters specific of murin or chimeric mAbs to humanized or human mAbs. Doses and administration frequency have been chosen based on this nature. More recently, the developed and registered mAbs are mostly IgG1, IgG2, IgG3 or IgG4 humanized or 100% human. Therefore, their behavior is different from the first mAbs authorized leading to lower systemic clearance and shorter half-life due to higher cellular uptake balanced by FcRn recognition with recirculation.

Source: European Journal of Cancer - February 5, 2020 Category: Cancer & Oncology Authors: Angelo Paci, Aude Desnoyer, Julia Delahousse, Louis Blondel, Christophe Maritaz, Nathalie Chaput, Olivier Mir, Sophie Broutin Tags: Review Source Type: research