Intraoperative radiotherapy for breast cancer treatment efficiently targets the tumor bed preventing breast adipose stromal cell outgrowth

ConclusionsAfter breast-conserving surgery, approximately 90% of local recurrences emerge in close proximity to the initial tumor bed, potentially reflecting a significant contribution of the tumor bed to relapse. Our data show that IORT, besides the proven effect on breast cancer cells, efficiently modifies the tumor environment by having an impact on tumor bed bASC. This effect on tumor bed stromal cells might contribute to reduce the risk of tumor rel apse and metastases.

http://link.springer.com/10.1007/s00066-020-01586-z

Source: Strahlentherapie und Onkologie - February 5, 2020 Category: Cancer & Oncology Source Type: research