Immune-related Neutropenia Following Treatment With Immune Checkpoint Inhibitors
The existing data with regard to immune-related neutropenia (irN), a rare (incidence—1%) immune-related adverse event of immune checkpoint inhibitors, are scarce. Eight patients with irN were identified through internal databases of 3 participating Israeli cancer centers. In addition, 11 original articles focusing on the clinical course of 24 patients with irN were selected during the PubMed search. Descriptive analysis of clinical and pathologic factors related to irN was performed (n=32); the effect of these on the irN outcomes was assessed. An algorithm for irN evaluation and treatment was proposed. The median time-to-onset of irN (n=32) was 60 days (range, 10–465 d). Grade 3–5 irN, febrile neutropenia, and irN-related death occurred in 81%, 50%, and 9% of patients, respectively. In all, 56%, 22%, 62%, and 25% of patients received PO corticosteroids, IV corticosteroids, granulocyte colony–stimulating factor (GCSF), and intravenous immunoglobulins (IVIG), respectively, with an improvement/resolution rate of 84%. Odds ratios for irN improvement/resolution were as follows: 1.40 [95% confidence interval (CI), 0.03–68.72], 0.43 (95% CI, 0.04–4.22), 2.60 (95% CI, 0.07–97.24), 0.36 (95% CI, 0.03–4.38), 4.02 (95% CI, 0.16–99.48), 2.01 (95% CI, 0.32–12.70), 1.08 (95% CI, 0.02–49.89), 0.42 (95% CI, 0.06–2.91), and 2.73 (95% CI, 0.42–17.51) for granulocyte hyperplasia, granulocyte/all lineage hypopla...
Publication date: Available online 1 April 2020Source: Journal of Molecular LiquidsAuthor(s): Xianting Xie, Lu Zhang, Wenjuan Zhang, Reza Tayebee, Atefe Hoseininasr, Hamid H. Vatanpour, Zeinab Behjati, Suying Li, Marjan Nasrabadi, Liuyi Liu
Publication date: Available online 1 April 2020Source: Carbohydrate PolymersAuthor(s): Chia-Hsiang Yen, Sheng-Tien Li, Nai-Chen Cheng, You-Ren Ji, Jyh-Horng Wang, Tai-Horng Young
Publication date: Available online 1 April 2020Source: Inorganica Chimica ActaAuthor(s): Sourav De, S.K. Ashok Kumar
Publication date: Available online 1 April 2020Source: European Polymer JournalAuthor(s): Himani Kalita, Manoj Patowary
Conclusion: CD26 is involved in the pathogenesis of colorectal diseases; sCD26 is diminished in CRC patients suggesting the potential utility of a sCD26 for diagnosis. PMID: 32223519 [PubMed - as supplied by publisher]
Publication date: Available online 2 April 2020Source: Preventive MedicineAuthor(s): Francesca Holme, Jose Jeronimo, Francisco Maldonado, Claudia Camel, Manuel Sandoval, Benito Martinez-Granera, Mirna Montenegro, Jacqueline Figueroa, Rose Slavkovsky, Kerry A. Thomson, Silvia de Sanjose, the Scale-Up project team
Publication date: Available online 1 April 2020Source: Preventive MedicineAuthor(s): Shelton J. Bartley, Vicki Benard, Eric Tai, Tanner Rockwell, Kristy Kenney, Lisa C. Richardson
Two University of Rochester physicians — one as an investigator and one as a patient — had major roles in a cutting-edge clinical trial using the body’s own immune cells to fight late-stage cancer. The striking results, showing that 93 percent of the study patients responded to the treatment, were reported in the April 2, 2020, iss ue of New England Journal of Medicine.
Publication date: Available online 2 April 2020Source: The American Journal of SurgeryAuthor(s): Zhi Ven Fong, David C. Chang, Chin Hur, Ginger Jin, Angela Tramontano, Naomi M. Sell, Andrew L. Warshaw, Carlos Fernandez del Castillo, Cristina R. Ferrone, Keith D. Lillemoe, Motaz Qadan
Conclusion: This study demonstrates the unequal manifestation of EOGC within the two ethnic groups of Han and Yi. However, familial clustering was infrequent. Further investigations are necessary to discover relevant risk factors apart from hereditary predisposition. PMID: 32231466 [PubMed - in process]