Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate.

Pioglitazone as a modulator of the chemoresistance of renal cell adenocarcinoma to methotrexate. Oncol Rep. 2020 Jan 29;: Authors: Piątkowska-Chmiel I, Gawrońska-Grzywacz M, Natorska-Chomicka D, Herbet M, Sysa M, Iwan M, Korga A, Dudka J Abstract Kidney cancer is one of the most lethal urological malignancies associated with a high risk of mortality. Recent studies have shown that several antidiabetic drugs may limit the risk of the growth of different types of cancer. Pioglitazone (PIO) belongs to a novel class of antidiabetic drugs called thiazolidinediones (TZDs), which are commonly used in the treatment of type 2 diabetes. This drug has been demonstrated to exert an inhibitory effect on cell growth in colon, prostatic, breast and pancreatic cancer lines. The aim of the present study was to assess the inhibitory effect of PIO on the proliferation of the renal adenocarcinoma cell line 769‑P. In addition, the proapoptotic potential of combined treatment with PIO and methotrexate (MTX) was evaluated, as well as the impact of the above drugs on the cell cycle of the 769‑P cells. The present study showed that PIO efficaciously inhibited the proliferation and viability of renal cancer cells, and it induced sub‑G1 cell cycle arrest and a decrease in the number of cells in the G2 phase, which indicated cytotoxic activity. PIO also exhibited proapoptotic properties at the lowest dose applied (10 µM). Furthermore, combined ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Related Links:

Phys. Chem. Chem. Phys., 2020, Accepted Manuscript DOI: 10.1039/C9CP06671C, PaperLe Li, Xuhua Li, Yiming Tang, Zenghui Lao, Jiangtao Lei, Guanghong Wei The p53 protein is a tumor suppressor and the most often mutated protein in human cancers. Recent studies reported that p53 mutants, including two of the common cancer mutants (R175H... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research
CONCLUSIONS Our analysis is the first to show that SPP1 and FN1 might work as biological markers of progression and prognosis in esophageal carcinoma (ESCA). PMID: 32208405 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 25 March 2020Source: Journal of OrthopaedicsAuthor(s): Ong-art Phruetthiphat, Rit Apinyankul, Malee Chanpoo, Thanainit Chotanaphuti, Weerachai Kosuwan, John J. Callaghan
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
Publication date: Available online 2 March 2020Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Olivia Evans, Faiza Gaba, Ranjit Manchanda
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
ConclusionsThe results of this prospective study indicate that dietary total polyphenol intake in Japanese is inversely associated with all-cause mortality and mortality from cardiovascular and digestive diseases.
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
Many health systems have defined which surgeries they consider permissible during the pandemic, typically by using time parameters (days/weeks/hours) by which a patient would not be caused harm.Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 26 March 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Awadhesh Kumar Singh, Akriti Singh, Altamash Shaikh, Ritu Singh, Anoop Misra
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 25 March 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Manish Bansal
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 25 March 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Ritesh Gupta, Anoop Misra
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
More News: Actos | Adenocarcinoma | Cancer | Cancer & Oncology | Colon Cancer | Colorectal Cancer | Diabetes | Endocrinology | Kidney Cancer | Methotrexate | Pancreas | Pancreatic Cancer | Renal Cell Carcinoma | Study | Urology & Nephrology