Periostin induces epithelial ‑to‑mesenchymal transition via the integrin α5β1/TWIST‑2 axis in cholangiocarcinoma.

In conclusion, the ITGα5β1‑mediated TWIST‑2 signaling pathway regulates PN‑induced EMT in CCA progression, and TWIST‑2 is a prognostic marker of poor survival in CCA patients.
PMID: 32020235 [PubMed - as supplied by publisher]

Source: Oncology Reports - February 7, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research