Common and distinct brain functional alterations in pharmacotherapy treatment-na ïve female borderline personality disorder patients with and without auditory verbal hallucinations: a pilot study.

This study aimed to investigate whole-brain functional connectivity (FC), as measured by functional connectivity density (FCD), and its relationship with AVH in BPD. 65 pharmacotherapy treatment-naïve female BPD patients (30 with AVH and 35 without AVH), and 35 female healthy controls were investigated. Functional magnetic resonance imaging (fMRI) data were collected to assess whole-brain FC and functional connectivity density mapping (FCDM) was applied to the fMRI data to compute FCD features. Compared to the healthy controls, both BPD groups (BPD-AVH and BPD without AVH) exhibited significantly higher gFCD values in the bilateral prefrontal lobe, bilateral orbital lobule, and bilateral insula, and significantly lower gFCD values in the SMA, right anterior temporal lobule, and the ACC. These altered regions were significantly associated with AVH in the BPD subjects. Moreover, higher gFCD values were observed in the left posterior temporal lobule and posterior frontal lobule. Aberrant alterations also emerged in the left posterior temporal lobule and posterior frontal lobule, mainly in Broca and Wernicke regions. Nevertheless, there was no significant correlation between gFCD values and the severity of AVH as measured by the AVH scores. In summary, we have identified aberrations in the FC and brain metabolism of the aforementioned neural circuits/networks, which may provide new insights into BPD-AVH and facilitate the development of therapeutic approaches for treating AV...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

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CONCLUSIONS.: Our results confirm orbitofrontal structural deficits in BPD, while providing a framework and preliminary findings on identifying structural correlates of symptom dimensions in BPD, especially with dorsolateral and orbitofrontal cortices. PMID: 32093800 [PubMed - in process]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
This study aimed to investigate whole-brain functional connectivity (FC), as measured by functional connectivity density (FCD), and its relationship with AVH in BPD. 65 pharmacotherapy treatment-na ïve female BPD patients (30 with AVH and 35 without AVH), and 35 female healthy controls were investigated. Functional magnetic resonance imaging (fMRI) data were collected to assess whole-brain FC and functional connectivity density mapping (FCDM) was applied to the fMRI data to compute FCD featur es. Compared to the healthy controls, both BPD groups (BPD–AVH and BPD without AVH) exhibited significantly higher gFCD v...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
Conclusions are limited due to the lack of a control group. A randomized controlled trial (RCT) will be needed to confirm effectiveness of the training.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Our work provides important new insights about treatment prediction in a specific mental disorder of high clinical relevance that is borderline personality disorder, using random forest classification based on functional and structural MRI data as well as clinical and demographical data. Our findings now show proof of principle that random forest models can provide predictions of therapy response with good test characteristics (here up to 76.08% mean accuracy, 0.77 mean sensitivity, and 0.81 mean specificity) and underline the power of random forest classifications in general. AbstractIntroductionIndividualized treatment p...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Previous research has demonstrated that patients with Borderline Personality Disorder (BPD) are more sensitive to negative emotions and often show poor cognitive empathy, yet preserved or even superior emotional empathy. However, little is known about the neural correlates of empathy. Here, we examined empathy for pain in 20 patients with BPD and 19 healthy controls in an fMRI study, which comprised an empathy for pain paradigm showing facial emotions prior to hands exposed to painful stimuli. We found a selectively enhanced activation of the right supramarginal gyrus for painful hand pictures following painful facial expr...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Impulsivity represents one of the pivotal characteristics of bipolar disorder (BD). Structural magnetic resonance imaging techniques have already demonstrated a relationship between high levels of impulsivity and reduced subcortical and limbic structure volumes in subjects with cocaine abuse, depression, and borderline personality disorder. However, such relationship has not established yet in BP. The aim of this study is to investigate the relationship between impulsivity and limbic and subcortical volumes in patients with BD.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
This study provides support for the notion that non-judgmental attention to the present moment facilitates the integration of regions in neural networks that are related to cognition, attention, and sensation. Introduction Originating in Buddhist traditions, mindfulness training has made its way into Western culture as a method to reduce stress, enhance emotional regulation, and reduce symptoms in a variety of mental health disorders (Teasdale et al., 1995; Farb et al., 2012; Cavanagh et al., 2013; Tabak et al., 2015). Indeed, mindfulness has been shown to reduce symptoms of depression (Chiesa et al., 2015), bipol...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
This study, therefore, compares reappraisal of negative, positive, neutral, and alcohol-related images at a behavioral and neural level between ADPs and healthy controls (HCs).Thirty-nine ADPs and 39 age-, gender-, and education-matched HCs performed an emotion reappraisal task during functional magnetic resonance imaging (fMRI), and craving was measured before and after the reappraisal task. During the emotion reappraisal task, participants were instructed to either attend or reappraise positive, negative, neutral, or alcohol-related images, and to indicate their experienced emotion on a visual analogue scale (VAS).Both A...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
CONCLUSIONS: The negative self-views that BPD have, may obstruct critically examining negative feedback, resulting in lower mood. Moreover, where HC focus on the positive feedback (based on TPJ activation), BPD seem to focus more on negative feedback, potentially maintaining negative self-views. Better balanced self-views may make BPD better equipped to deal with potential negative feedback and more open to positive interactions. PMID: 30867073 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
AbstractRecent resting-state functional connectivity studies have shown significant group differences in several networks between patients suffering from borderline personality disorder (BPD) and healthy controls. However, reliable and consistent findings have not been reported yet. Several methodological factors might be responsible for the discrepant findings, including the heterogeneity of patient samples in terms of symptom severity. In the current study, we combined investigations of the whole-brain resting-state functional connectivity patterns of BPD patients with seed-based connectivity measures and then computed t...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
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