The peptide compound urantide regulates collagen metabolism in atherosclerotic rat hearts and inhibits the JAK2/STAT3 pathway.

In conclusion, urantide was able to effectively block the UII/GPR14 system by regulating the JAK2/STAT3 pathway and collagen metabolism. Inhibition of the UII/GPR14 system may prevent and potentially treat atherosclerotic myocardial fibrosis. Based on the current results, it was hypothesized that collagen metabolism may be associated with the JAK2/STAT3 pathway. PMID: 32016456 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32016456?dopt=Abstract

Source: Molecular Medicine Reports - February 7, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research