Novel Ruthenium(II) Complexes With Cimetidine: Dft Calculations and In Vitro Cytotoxic Activities Against Glioblastoma Cell Lines

Publication date: Available online 5 February 2020Source: Inorganica Chimica ActaAuthor(s): Júlia Scaff Moreira Dias, Henrique Vieira Reis Silva, Caio Cesar Candido, Guilherme Álvaro Ferreira da Silva, Marisa Ionta, Fernando Almeida, Rommel Bezerra Viana, Marília Imaculada Frazão Barbosa, Antônio Carlos DoriguettoAbstractHerein, four novel ruthenium(II) complexes containing cimetidine as a ligand were obtained, [RuCl(CIM)(dppb)(bipy)]Cl (1), [RuCl(CIM)(dppb)(4,4’-Me-bipy)]Cl (2), [RuCl(CIM)(dppb)(5,5’-Me-bipy)]Cl (3), [RuCl(CIM)(dppb)(phen)]Cl (4), where CIM (cimetidine) = cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl) methylsulfanyl] ethyl]guanidine], dppb = 1,4-bis(diphenylphosphine)butane, bipy = 2,2’-bipyridine, 4,4’-Me-bipy = 4,4’-dimethyl-2,2’-bipyridine, 5,5’-Me-bipy = 5,5’-dimethyl-2,2′-bipyridine and phen = 1,10-phenanthroline. The complexes were characterized by elemental analysis; molar conductivity measurements; infrared and UV-Vis spectroscopy; 31P{1H}, 13C and 1H NMR; mass spectrometry and cyclic voltammetry. Density functional theory (DFT) calculations were performed and compared with experimental data. Coordinated cimetidine cleavage was also observed. The cytotoxicity profiles of compounds (1-4) were determined in a glioblastoma cell line (U251-MG), and compared to the free ligand cimetidine, these compounds were able to reduce the viability of U251-MG cells.Graphical abstractFour ruthenium cimetidine complexes were synthesized a...

Source: Inorganica Chimica Acta - February 6, 2020 Category: Chemistry Source Type: research