Modeling and analysis of recurrent autoimmune disease

Publication date: August 2020Source: Nonlinear Analysis: Real World Applications, Volume 54Author(s): Yancong Xu, Yu Yang, Fanwei Meng, Pei YuAbstractIn this paper, we consider dynamics and bifurcations in two HIV models with cell-to-cell interaction. The difference between the two models lies in the inclusion or omission of the effect of involvement. Particular attention is focused on the effects due to the cell-to-cell transmission and the effect of the involvement. We investigate the local and global stability of equilibria of the two models and give a comparison. We derive the existence condition for Hopf bifurcation and prove no Bogdanov-Takens bifurcation in this system. In particular, we show that the system exhibits the recurrence phenomenon, yielding complex dynamical behavior. It is also shown that the effect of the involvement is the main cause of the periodic symptoms in HIV or malaria disease. Moreover, it is shown that the increase of cell-to-cell interaction may be the main factor causing Hopf bifurcation to disappear, and thus eliminating oscillation behavior. Finally, numerical simulations are present to demonstrate our theoretical results.
Source: Nonlinear Analysis: Real World Applications - Category: Research Source Type: research