Jeopardy of Lyssavirus infection in relation to hemato-biochemical parameters and diagnostic markers of cerebrospinal fluid in rabid calves

AbstractRabies is caused by a single-stranded virus with ribonucleic acid belonging to the genusLyssavirus in theRhabdoviridae family. This disease causes 100% fatality of exposed non-vaccinated humans and animals. Many aspects of rabies still ambiguous; therefore,  the hemato-biochemical effects ofLyssavirus infection and  the potential diagnostic markers of cerebrospinal fluid (CSF) in rabid calves were investigated. Six female Frisian cross-bred calves (6–7 months of age) were accidentally exposed to bites from stray dogs. Twenty days later, the calves showed anorexia, severe ptyalism, erected ears, fatigue, cough, and neurological signs including continuous mooing for the majority of the day and sometimes rubbing their heads against hard objects. The rabid calves died within 4–6 days after the appearance of these aforementioned signs. The cerebellum showed lymphocytic leptomeningitis with or without hemorrhage, along with characteristic Negri bodies; in the respiratory system, pronounced suppurative bronchopneumonia occurred. There were mild vicissitudes in the erythrogram without significant vicissitudes in the blood indices. The leucogram showed significant leucopenia, lymphopenia, and monoc ytopenia with marked granulocytosis. Blood gas analysis publicized mixed respiratory and metabolic acidosis. Laboratory findings of cerebrospinal fluid (CSF) revealed pleocytosis, lymphocytosis, and significant increases in glucose, cholesterol, S–100B, total proteins, ...

Source: Comparative Clinical Pathology - February 5, 2020 Category: Pathology Source Type: research