Renovascular hypertension elevates pulmonary ventilation in rats by carotid body-dependent mechanisms.

RENOVASCULAR HYPERTENSION ELEVATES PULMONARY VENTILATION IN RATS BY CAROTID BODY-DEPENDENT MECHANISMS. Am J Physiol Regul Integr Comp Physiol. 2020 Feb 05;: Authors: Del Rosso de Melo M, Gasparini S, Silva EF, Karlen-Amarante M, Speretta GFF, Lauar MR, Pedrino GR, Menani JV, Colombari DSA, Zoccal DB, Colombari E Abstract The two kidney-one clip (2K1C) renovascular hypertension depends on renin-angiotensin system and sympathetic overactivity. The maintenance of 2K1C hypertension also depends on inputs from the carotid bodies (CB), which when activated stimulate the respiratory activity. In the present study, we investigated the importance of CB afferent activity for the ventilatory responses in 2K1C hypertensive rats and for phrenic and hypoglossal activities in in situ preparations of normotensive rats treated with angiotensin II. Silver clips were implanted around the left renal artery of male Holtzman rats (150 g) to induce renovascular hypertension. Six weeks after clipping, hypertensive 2K1C rats showed, in conscious state, elevated resting tidal volume and minute ventilation in comparison to normotensive group. The 2K1C rats also presented arterial alkalosis, urinary acidification and amplified hypoxic ventilatory response. Carotid body removal (CBR), two weeks before the experiments (4th week after clipping), significantly reduced arterial pressure and pulmonary ventilation in 2K1C rats, but not in normotensive rats. Intra-arterial administration o...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

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