Comparison of MS inflammatory activity in women using continuous versus cyclic combined oral contraceptives

Conclusion: In this exploratory study, women on continuous OCs showed a trend towards less inflammatory activity on MRI relative to women on cyclic OCs. This difference was not reflected in relapse rates. We estimate that 342 patients would be required for an adequately powered cohort study to evaluate such an effect. Our findings provide reassurance that for women using continuous OCs to alleviate menstrual fluctuations in symptoms, there is not an increase in MS-related inflammatory activity.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Publication date: Available online 5 April 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Emmanuelle Waubant, Anne-Katrin Pröbstel, Michael Levy, Chris Hawkes, Gavin Giovannoni, Jeanette Lechner-Scott, Helen Tremlett
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 5 April 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Edgar Carnero Contentti, Jorge Correa
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
MONDAY, April 6, 2020 -- Greater genetic predisposition for multiple sclerosis (MS) is associated with altered brain white matter development at an early age, according to a study published online March 12 in the Annals of Neurology. C. Louk de...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
  Day 1,364 of the COVID-19 quarantine (well, at least it feels like it). How are you holding up? If you’re like most people, you’re not having much fun. But if you already struggle with anxiety, depression or another mental health issue, these days of isolation and uncertainty can feel like absolute torture. In today’s Not Crazy episode, Gabe laments the loss of his routine — those regular activities he clung to religiously to keep his mental health in check.  Now what is he supposed to do? Tune in for a special quarantine episode. Together, we will grieve our old routines and discuss...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic General Health-related Mental Health and Wellness Not Crazy Podcast Self-Help Source Type: blogs
(Thomas Jefferson University) Ursolic acid, abundant in fruit peels and some herbs, both prevents and repairs neurons in animal models of multiple sclerosis.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Multiple sclerosis (MS) is the most common autoimmune disease of the CNS. The etiology of MS is still unclear but it is widely recognized that both genetic and environmental factors contribute to its pathogene...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Review Source Type: research
Purpose of review Diverse adverse events have been associated with administration of glatiramer acetate (GA), mainly local reactions at the injection site. Other, less frequent generalized reactions include isolated postinjection reactions and anaphylaxis, which may lead to discontinuation of GA. Recent findings Close collaboration between the allergy and neurology departments is needed to study adverse reactions to GA. The allergy study should include a detailed history and skin prick and intradermal tests with GA and, if possible, determination of specific IgE levels. Furthermore, the implication of other drugs should b...
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Multiple sclerosis Review Source Type: research
CONCLUSION: Ageing is characterized by a peripheral subversion of the immune system with a condition of inflamm-ageing. Neuroinflammation and neurodegenerative diseases seem to be a central manifestation of a peripheral perturbation of the immune machinery. Dietary products and nutraceuticals may lead to a down-regulation of the oxidative and pro-inflammatory profile in ageing. PMID: 32250234 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Facial pain – an interdisciplinary challenge Swiss Dent J. 2020 Apr 06;(4):321-327 Authors: Gierthmuehlen M, Gierthmuehlen P, Hugger A, Gierthmuehlen J, Tuerp JC Abstract Acute pain has a warning function and is necessary to survive. Conversely, chronic or recurrent pain is a pathological entity itself and has tremendous impact on the quality of life of the patients . Facial pain is very common and can have various causes. The trigeminal nerve innervates the face, and tumours along its intracranial way as well as peripheral injury can lead to facial pain. Also, infections and systemic diseases, l...
Source: Schweizer Monatsschrift fur Zahnmedizin - Category: Dentistry Tags: Swiss Dent J Source Type: research
The objectives of this review were to examine the relationship between smoking and MS and to understand the possible molecular mechanisms underlying the association.PubMed was searched for articles related to the study topic published between 2012 and 2020 using the search terms "multiple sclerosis," "smoking," "risk factors," "cigarettes," and "molecular mechanisms."Studies show a significant relationship between smoking and the risk of MS.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Review Source Type: research
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