Antifungal, anti-inflammatory and antioxidant activity of bi-herbal phytotherapic using medicinal plants from Argentina highlands
ConclusionsOur results indicated that the most active combinations of these species extracts could be useful in the treatment of vaginal infectious diseases caused by Saccharomyces cerevisiae and Candida spp. strains and in the associated oxidative and inflammatory processes. In addition, the results highlighted the potential phyto-therapeutic of total phytochemical compounds present in these medicinal plants.Graphical abstract
Publication date: Available online 4 April 2020Source: Journal of Bioscience and BioengineeringAuthor(s): Kazuo Masaki, Taichi Mizukure, Dararat Kakizono, Kanako Fujihara, Tsutomu Fujii, Nobuhiko Mukai
Authors: Chakrabarti A, Singh S Abstract Introduction: Since the emergence of Candida auris infection in 2009, the disease has been reported from multiple countries within a decade. The infection is classified under urgent threat, as it is multi-drug resistant, causes high mortality, spreads easily in hospital setting and is difficult to identify. Whole-genome sequencing has provided insights into this organisms biology and epidemiology. A comprehensive review of those issues would help the clinicians and scientists facing C. auris infection.Areas covered: We reviewed the epidemiological trends of C. auris infectio...
This study evaluated the inhibitory effect of Brazilian red propolis on mono-s...
Publication date: Available online 1 April 2020Source: Medical Mycology Case ReportsAuthor(s): Bryant Koh, Catriona Halliday, Raymond Chan
Publication date: Available online 1 April 2020Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Weidong Qian, Min Yang, Xinchen Li, Zhaohuan Sun, Yongdong Li, Xuejun Wang, Ting Wang
Conclusion: Our results reported here for the first time, in particular for the biofilm state of C. albicans, imply that curcumin a natural product could be used as a therapeutic alternative to conventional antifungals although further investigations are required to evaluate its potential.
Publication date: Available online 31 March 2020Source: International Journal of Surgery Case ReportsAuthor(s): Laurence Vergison, Alexander Schepens, Koen Liekens, Renata De Kesel, Hans Van der Bracht, Jan Victor
Although obtaining fungal cultures from bronchoscopy samples rarely changed therapy, the study by Shah et al1 did not show whether such patients would benefit from antifungal drug treatment. Infectious Diseases Society of America guidelines2 state that "[g]rowth of Candida from respiratory secretions usually indicates colonization and rarely requires treatment with antifungal therapy." Following those guidelines, therapy will not be given. In my experience, Candida sometimes causes chronic bronchitis, which improves with antifungal drug therapy,3 and Candida can contribute to mucus plugging and atelectasis.
We thank Dr Johnson for his feedback.1 We agree that change of therapy vs benefit of therapy could not be assessed by our retrospective design. Regarding the comments on bronchiectasis, the role of antifungal agents in this population has not been thoroughly studied. Some retrospective studies, such as the letter writer's own, suggest that there may be benefit of researching this further in a prospective manner, but the preponderance of evidence is insufficient to recommend routinely treating Candida in respiratory infections outside of an appropriately monitored clinical trial.
Abstract Candida albicans is the causative agent of candidiasis in immunocompromised and diseased individuals. The current study was designed to evaluate the antifungal activity of Trachyspermum ammi (L.) Sprague seeds ethanolic extract and hexanes fraction against Candida albicans, both in-vitro and in-vivo. The minimal inhibitory concentration of hexanes fraction was found to be 225 μg/mL, as compared to the standard drug amphotericin B (200 μg/mL). For the treatment of cutaneous candidiasis in BALB/c mice model, the extract and fraction containing ointment was topically applied on flank of m...