The PI3K pathway impacts stem gene expression in a set of glioblastoma cell lines

ConclusionGiven that, PI3K inhibitors are actively investigated as targeted cancer therapies, the FOXO-mediated induction of stem genes observed in this study highlights a potential hazard to PI3K inhibition. Understanding the molecular underpinnings of stem signatures in cancer will allow refinements to therapeutic strategies. Targeting FOXO factors to reduce stem cell characteristics in concert with PI3K inhibition may prove therapeutically efficacious.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research