Cellular Retinoic-Acid Binding Protein 2 in solid tumor.

Cellular Retinoic-Acid Binding Protein 2 in solid tumor.
Curr Protein Pept Sci. 2020 Feb 03;:
Authors: Jiao X, Liu R, Huang J, Lu L, Li Z, Xu L, Li E
Abstract
The retinoic acid (RA) signaling pathway is crucial for many biological processes. The RA transporter, Cellular Retinoic-Acid Binding Protein 2 (CRABP2), abnormally expressed in various tumor types. CRABP2 presents significant effects on tumorous behaviors and functions, including cell proliferation, apoptosis, invasion, migration, metastasis, and angiogenesis. The tumorigenesis mechanism of CRABP2 as both suppressor and promotor is complicated, which remains ample space for further investigation. Elucidating the regulating mechanisms in a specific stage of the tumor could facilitate CRABP2 to be one biomarker in cancer diagnosis and prognosis. Besides, clarifying the pathways of CRABP2 in cancer development will contribute to the gene-targeted therapy. In this review, we summarized the expression, distribution, and mechanism of CRABP2 in solid tumors. Illuminating the CRABP2 signaling pathway may benefit understanding the retinoid signaling pathway, providing a useful biomarker for future clinical trials.
PMID: 32013828 [PubMed - as supplied by publisher]

Source: Current Protein and Peptide Science - February 2, 2020 Category: Biochemistry Authors: Jiao X, Liu R, Huang J, Lu L, Li Z, Xu L, Li E Tags: Curr Protein Pept Sci Source Type: research