Crafting With Dry Pasta, Play-Doh Safe for Kids With Gluten Sensitivity: Study
Title: Crafting With Dry Pasta, Play-Doh Safe for Kids With Gluten Sensitivity: StudyCategory: Health NewsCreated: 2/4/2020 12:00:00 AMLast Editorial Review: 2/5/2020 12:00:00 AM
Biologics for the Treatments of Allergic Conditions
Mark Ballow and Elena E. Perez
LINDA S. COX, MD, FACP, AAAAI
Immunol Allergy Clin N Am
Ikaros zinc finger 1 (IKZF1 or Ikaros) is a hematopoietic zinc finger DNA-binding transcription factor that acts as a critical regulator of lymphocyte and myeloid differentiation. Loss-of-function germline heterozygous mutations in IKZF1 affecting DNA-binding were described as causative of 2 distinct primary immunodeficiency (PID)/inborn error of immunity diseases. Mutations acting by haploinsufficiency present with a common variable immune deficiency-like phenotype mainly characterized by increased susceptibility to infections. Mutations acting in a dominant negative fashion present with a combined immunodeficiency phenot...
This article reviews targeted precision-based therapy for treatment of cytotoxic T-lymphocyte antigen haploinsufficiency, lipopolysaccharide-responsive beige-like anchor deficiency, activated PI3K defic iency syndrome, signal transducer and activator of transcription– 1 and -3 – gain-of-function disorders, and disorders of inflammasome activation.
The number of disorders associated with congenital or acquired asplenia and functional hyposplenism has increased substantially over the past couple decades. Previously, screening for asplenia and hyposplenism was a barrier to identifying patients at risk. Recent methods for measuring splenic function have emerged as accurate and reliable. Identifying patients prevents overwhelming postsplenectomy infection or invasive pneumococcal disease. Approaches to protect patients with asplenia or hyposplenism include patient education of risks and signs/symptoms of infection, vaccination, and antibiotic prophylaxis. Physicians have...
Evaluation of antibodies produced after immunization is central to immune deficiency diagnosis. This includes assessment of responses to routine immunizations as well as to vaccines administered specifically for diagnosis. Here, we present the basic concepts of the humoral immune response and their relevance for vaccine composition and diagnosis of immune deficiency. Current vaccines are discussed, including nonviable protein and glycoprotein vaccines, pure polysaccharide vaccines, polysaccharide –protein conjugate vaccines, and live agent vaccines. Diagnostic and therapeutic applications of vaccine antibody measurem...
Authors: Kim S, Jin HJ, Kim SR PMID: 32638569 [PubMed]