Effect of Treatment of Central Sleep Apnea/Cheyne-Stokes Respiration on Left Ventricular Ejection Fraction in Heart Failure: A Network Meta-Analysis is not the Answer

Journal of Clinical Sleep Medicine, Ahead of Print.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Authors: Source Type: research

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Publication date: March–April 2020Source: Heart &Lung, Volume 49, Issue 2Author(s): William Abraham, Ralph Augostini, Ayesha Hasan, Seamus Jackson, Rami Kahwash, Julie Mease, Emani Sitaramesh
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Journal of Clinical Sleep Medicine, Ahead of Print.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Authors: Source Type: research
Tatjana PS Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with increased risk of death, stroke and heart failure. The prevalence and incidence of AF is increasing due to better overall medical treatment, longer survival and increasing incidence of cardiometabolic and lifestyle risk factors. Treatment of AF and AF-related complications significantly increase health-care costs. In addition, use of conventional rhythm control strategies (i.g. antiarrhyhtmic drugs and catheter-ablation) is associated with limited efficacy for sinus rhythm maintenance and serious adverse effe...
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
CONCLUSIONS: We confirm that SAHS is common in CABG-surgery patients, presenting additional clinical challenges and cost implications. The underlying pathophysiology is complex, including upper airway obstruction and cardiorespiratory changes of heart failure. In patients presenting for CABG-surgery, we show chronic susceptibility to SAHS, likely associated with traditional risk factors e.g. obesity but perhaps also with gradual decline in heart function itself. Superimposed on this, there is potential for exacerbated risk of morbidity at the time of CABG surgery itself. PMID: 32186169 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: J Cardiovasc Surg (Torino) Source Type: research
Central sleep apnea (CSA) is a neurological breathing disorder, resulting from intermittent disruptions in the neural drive to breath. CSA differs substantially from the more prevalent Obstructive Sleep Apnea (OSA), which occurs as a result of muscles relaxing in the upper airway and preventing the passage of airflow. Sleep apnea is classified as "central" when over 50% of the apnea-hypopnea index (AHI) is driven by central events.CSA is a common and serious comorbidity in patients with heart failure (HF), with a prevalence of 30-50% in patients with a reduced left ventricular ejection fraction LVEF 45%.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research
AbstractPurpose of ReviewThe main objective of the 1st part of this review is to demonstrate that a better understanding of comorbidities such as COPD, obstructive sleep apnea, thyroid dysfunction, cardiorenal syndrome, its pathophysiological and therapeutic implications, impact on the management of FH by interfering with its survival, and quality of life of patients.Recent FindingsThe prevalence of heart failure will increase 46% from 2012 to 2030, resulting in>  8 million people ≥ 18 years of age. This disease has a large burden of noncardiovascular comorbidities, which may increase the risk of m...
Source: Current Emergency and Hospital Medicine Reports - Category: Emergency Medicine Source Type: research
fic council Abstract BACKGROUND: Diuretics have been reported as effective for reducing obstructive sleep apnea (OSA) severity by preventing fluid retention and reducing rostral fluid shift. The benefit of diuretics might vary depending upon the OSA clinical phenotype and comorbidities. To test this hypothesis, we conducted a propensity score-matched cohort analysis of data from the French national sleep apnea registry "Observatoire Sommeil de la Fédération de Pneumologie" (OSFP). METHODS: A propensity score analysis was used to determine the impact of diuretics on OSA severity. Matchi...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
This study shows the effectiveness of adaptive servo ventilation in treating patients with central sleep apnea, irrespective of a predisposing factor, as assessed during a 4-week treatment trial. Results show that adaptive servo ventilation was effective and superior to continuous positive airway pressure in controlling central sleep apnea and improving symptoms. Only a small proportion of these patients had comorbid heart failure. Early treatment with adaptive servo ventilation may improve long-term adherence to therapy. These findings highlight the utility of adaptive servo ventilation in the management of central sleep ...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research
AbstractObstructive sleep apnea (OSA) syndrome is the most common sleep-breathing disorder, which is associated with increase cardiovascular morbidity and mortality. OSA increases risk of resistant arterial hypertension, coronary artery disease, heart failure, pulmonary hypertension, and stroke. Studies showed the significant relationship between OSA and cardiac remodeling. The majority of investigations were focused on the left ventricle and its hypertrophy and function. Fewer studies investigated right ventricular structure and function revealing deteriorated diastolic and systolic function. Data regarding left and right...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Abstract Central sleep apnea/Hunter-Cheyne-Stokes Breathing (CSA/HCSB), is prevalent in patients with heart failure with reduced ejection fraction (HFrEF). The acute pathobiological consequences of CSA/HSCB eventually lead to sustained sympathetic over-activity, repeated hospitalization, and premature mortality. Few small randomized controlled trials (RCTs) have shown statistically significant and clinically important reduction in sympathetic activity when CSA/HCSB is attenuated by oxygen or positive airway pressure (PAP) therapy, both continuous PAP (CPAP) and Adaptive servo ventilation (ASV) devices. Yet, the tw...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
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