Luminal plugging on chest CT: association with lung function, quality of life, and COPD clinical phenotypes.

Luminal plugging on chest CT: association with lung function, quality of life, and COPD clinical phenotypes. Chest. 2020 Feb 01;: Authors: Okajima Y, Come CE, Nardelli P, Sonavane SK, Yen A, Nath HP, Terry N, Grumley SA, Ahmed A, Kligerman S, Jacobs K, Lynch DA, Make BJ, Silverman EK, Washko GR, San José Estépar R, Diaz AA Abstract BACKGROUND: Mucous exudates occluding the lumen of small airways are associated with reduced lung function and mortality in COPD subjects; however, luminal plugs in large airways have not been widely studied. We aimed to examine the associations of chest computed tomography (CT)-identified luminal plugging with lung function, health-related quality of life, and COPD phenotypes. METHODS: We randomly selected 100 smokers without COPD and 400 with COPD from the COPDGene Study. Luminal plugging was visually identified on inspiratory CT scans at baseline and five-year follow-up. The relationships of luminal plugging to FEV1, St. George's Respiratory Questionnaire (SGRQ) score, emphysema on CT (defined as the percentage of low attenuation area
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research

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Smoke-measuring smart shirts, breath sound analyzing algorithms, and smart inhalers pave the way of pulmonology and respiratory care into the future. As the number of patients suffering from asthma, COPD, or lung cancer due to rising air pollution and steady smoker-levels will unfortunately not decrease any time soon, we looked around what technology can do to help both patients and caregivers. The results are breathtaking. Attacks of breathlessness are too common The diseases which pulmonologists and respiratory care specialists attempt to fight are among the most common conditions in the modern world – and t...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Future of Medicine Health Sensors & Trackers AI asthma cancer cancer treatment care COPD diagnostics inhaler lung lung cancer management medical specialty pulmonology respiratory respiratory care Source Type: blogs
Gala Therapeutics said today that it launched an early feasibility study of its RheOx system for treating chronic bronchitis, and that the first two patients in the trial have already been enrolled. Initial patient enrollment took place at the University of Pittsburgh Medical Center, with RheOx bronchial rheoplasty procedures performed by Dr. Frank Sciurba and Roy Semaan, the Menlo Park, Calif.-based company said. “We are pleased to partner with Gala in treating the first US patients and thus continuing the contribution of UPMC as a leader in the development of novel devices for our patients with COPD. RheOx off...
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Respiratory galatherapeutics Source Type: news
We’ve shown FOT staged COPD correlates better with patient reported outcomes (PROs) than spirometry (SP) staged COPD. We hypothesized non-obstructed subjects (non-OB, FEV1/FVC≥0.7) with either MMEF130% predicted would be more similar to obstructed subjects (OB, FEV1/FVC10 pack-year smoking and either FEV1/FVC
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research
Aim: to establish the variability and origin of the composition of oropharyngeal microbiota in patients with different clinical and functional characteristics of COPD.Methods: included g64 COPD patients without exacerbations for 4 weeks. At the visit were performed the collection of anamnestic data, lung function evaluation, body plethysmography, lung diffusion capacity study, CT scan of the chest and collection of oropharingeal swabs to identify the composition of the microbiota by sequencing 16S rRNA gene sequences of bacteria. To determine the pattern of respiratory microbiota associated with specific phenotypic charact...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems COPD Source Type: research
Conclusions: Alterations to RV structure may represent a mechanism by which long-term PM10–2.5 exposure increases risks for adverse respiratory and cardiovascular outcomes, especially among certain susceptible populations. Received: 14 June 2016 Revised: 24 February 2017 Accepted: 16 March 2017 Published: 27 July 2017 Address correspondence to S. D. Adar, University of Michigan School of Public Health, 1415 Washington Heights, SPH II-5539, Ann Arbor, MI 48109 USA. Telephone: (734) 615-9207; Email: Supplemental Material is available online (
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of mortality across the world. According to WHO, COPD is a serious lung ailment that is marked by a persistent blockage of airflow from the lungs [1]. Global initiative for chronic Obstructive Lung Disease (GOLD) defines COPD as a state of disease that is characterized by limited airflow and is not fully reversible [2]. COPD is not curable, but treatment can slow the progress of the disease. Obstruction in air flow is due to two main conditions: Emphysema and Chronic Bronchitis.
Source: Computer Methods and Programs in Biomedicine - Category: Bioinformatics Authors: Source Type: research
Over the last half century, technology has made possible the probing of the solar system and galaxy beyond. People can instantly correspond with anyone in the world. We can see —in real time—events and phenomena heretofore only reported by second and third hand accounts. Yet with all of the distance breached by modern devices, we are also able to know in detail the goings on inside our own bodies. With the advent of computed tomography (CT) imaging, known familiarly as “CAT scans,” doctors and their patients now get a bird’s eye view of internal organs. This scientific know-how goes beyond sim...
Source: ePharma Summit - Category: Pharmaceuticals Tags: Anatomy CT Scan Lungs Medical Devices Source Type: blogs
Conclusions: COPDHO had an elevated risk of LC with annual incidences of up to39 cases/1,000 pts/year. In our study, the presence of emphysema on CT was not associated with the occurrence of LC.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 11.1 Lung Cancer Source Type: research
Hippocrates may well have appreciated the significance of the presence of emphysema, but it was not until the 17th century that Bonet1 described the larger lungs of those with emphysema, to which he attributed their breathlessness. In 1821, Laennec connected emphysema to ageing, when he ascribed a subtly different definition to emphysema, describing it as "a breakdown of tissue in the parenchyma of the lungs as opposed to air trapped in the alveoli due to obstruction as occurs in asthma and chronic bronchitis" essentially considering emphysema to be an ‘independent finding’ to obstructive lung disease...
Source: Thorax - Category: Respiratory Medicine Authors: Tags: Editorial Source Type: research
This study affirms that these people can experience serious health consequences, even without COPD. This finding also brings into question how we should classify chronic respiratory disease. So far, we haven’t determined a way of classifying those who have symptoms but don’t quite meet the usual criteria for COPD, and we also don’t have much data or guidance on how best to treat them. In the meantime, quitting smoking remains the best way to lower your chances of getting COPD — and the best way to lessen any respiratory symptoms you’re having. Most smokers who stop will feel better, with less ...
Source: New Harvard Health Information - Category: Consumer Health News Authors: Tags: Health Lung disease Smoking cessation COPD Source Type: news
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