Kinetics of DNA damage repair response accompanying initial hepadnavirus-host genomic integration in woodchuck hepatitis virus infection of hepatocyte

Hepatitis B Virus (HBV), a prototype of hepadnaviral family, is a highly oncogenic virus and its integration to human hepatocyte genome is considered to be a decisive driver of liver carcinogenesis culminating in the onset of primary liver cancer, hepatocellular carcinoma (HCC) [1]. Mechanisms of HBV integration are not well defined and those enabling the earliest (initial) virus-host DNA fusions are essentially unknown. This impedes our understanding of the initiation and molecular dynamic of progression of HBV-associated oncogenesis.

Source: Cancer Genetics and Cytogenetics - February 4, 2020 Category: Genetics & Stem Cells Authors: Ranjit Chauhan, Tomasz I. Michalak Source Type: research