Pregnancy outcomes in women with primary biliary cholangitis and primary sclerosing cholangitis: A retrospective cohort study.
CONCLUSION: Pregnancy in PBC and PSC is well tolerated, but women should be counselled regarding the increased risk of preterm birth. Measurement of maternal ALT and bile acids may help identify women at risk of preterm delivery. PMID: 32012415 [PubMed - as supplied by publisher]
Consultations in Liver Disease
Vinod K. Rustgi
NORMAN GITLIN, MD, FRCP (LONDON), FRCPE (EDINBURGH), FAASLD, FACP, FACG
CLINICS IN LIVER DISEASE
Hippocrates (460-371 bc) first recognized the relationship between the neuropsychological and physiologic changes observed in liver disease (Figs. 1 and 2). At that time, Hippocrates noted that there was a poor clinical outcome associated with delirium that was preceded by jaundice.1
Contributors : Michele Vacca ; Antonio Vidal-Puig ; Brian Y Lam ; Marcella MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTGF β/BMP family member Bone Morphogenetic Protein 8b (Bmp8b) is upregulated in NASH (Western Diet -WD- Model), acute liver damage (CCl4 model) and by Partial Hepatectomy (PH). Absence of Bmp8b reduces liver inflammation and fibrosis in the NASH model (WD). In the acute (3days) CCl4 model, absence of B mp8b impacts acute inflammatory responses, hepatic stellate cells (HSC) activation, and compensatory hepatocyte proliferation; defective inflammatory pathway...
Contributors : Lucas C Pantaleao ; Susan E Ozanne ; Ania WilczynskaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity during pregnancy is associated with fetal growth restriction in the offspring. We used RNA next generation sequencing analysis (HiSeq2000) to have a snapshot of the placenta transcriptome at embryonic day 19 to examine whether mice exposed to maternal obesity had significant changes in their transcriptome which may lead to growth restriction in the fetus.
The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, immunological and psychosocial assessment. The roles of various risk factors and comorbid conditions governing an individual’s suitability for transplantation such as adherenc...
Conclusions. In Japan, where>70% of retransplantations are performed using living donors, the indications and timing are different from those in previous reports from other countries, while maintaining comparable survival rates. Considering technical challenges, graft failure within 365 days should be thoroughly restricted to justify the use of living donor.