Prenatal Vitamin D Does Not Reduce Asthma, Wheeze at Age 6
WEDNESDAY, Feb. 5, 2020 -- Among children at risk for asthma, prenatal vitamin D supplementation does not affect the incidence of asthma or recurrent wheeze at age 6, according to a study published in the Feb. 6 issue of the New England Journal of...
Conclusion: Our data suggest that peripartum exposure to neuraxial anesthesia may reduce the risk of childhood asthma primarily in males. Larger human studies and model systems with longer follow-up are required to elucidate these findings. PMID: 32212939 [PubMed - as supplied by publisher]
Publication date: April 2020Source: Journal of Adolescence, Volume 80Author(s): Samantha A. Miadich, Robin S. Everhart, Jessica Greenlee, Marcia A. Winter
Acute severe asthma represents a common medical emergency, accounting for>65,000 UK hospital admissions each year, and asthma still accounts for approximately 1400 UK deaths annually. Risk factors for fatal asthma include poorly controlled disease, inappropriate medical management and adverse behavioural and social factors. Asthma is characterized by chronic airway inflammation, resulting in periodic wheeze, cough and breathlessness. A variety of triggers, most commonly viral respiratory tract infections, can cause exacerbations.
AbstractThrough the catalysis of α2,6-linked sialylation, the enzyme ST6Gal1 is thought to play key roles in immune cell communication and homeostasis. Of particular importance, glycans with terminal α2,6-sialic acids are known to negatively regulate B cell receptor signaling and are associated with an immunosuppressive tumor mic roenvironment that promotes T cell anergy, suggesting that α2,6-sialic acids are a key immune inhibitory signal. Consistent with this model, mice harboring a hepatocyte-specific ablation of ST6Gal1 (H-cKO) develop a progressive and severe non-alcoholic fatty liver disease charact...
ConclusionOur results showed that there is no difference in the FEV1 and forced vital capacity betweenAspergillus positive and negative patients in any asthma severity group.
If you ’re one of millions of Americans exposed to air pollution, you may be at a greater risk of catching the coronavirus — and of having a more severe infection.