Strategy of Drug Development Based on the Bioactive Gas-carrying Capacity of Hemoglobin.
In this study, we attempted to develop a biomimetic CO delivery system using a preparation of hemoglobin. Our strategy for the preparation of this hemoglobin-based CO carrier involves CO being exogenously bound to red blood cells or hemoglobin-encapsulated liposomes, called hemoglobin-vesicles (HbV), which mimic the structure and function of red blood cells. We accumulated evidence that the CO donors-CO-bound red blood cells and CO-bound HbV-showed therapeutic efficacy against intractable disorders in animal models. Here, we describe the potential of hemoglobin-based CO donors, especially CO-bound red blood cells and CO-bound HbV, for the treatment of certain disorders. Hemoglobin-based strategies for the delivery of other bioactive gases for novel drug development are also discussed. PMID: 32009035 [PubMed - in process]
In a recent issue of Annals, Cho et al investigated the risk of deep venous thrombosis after carbon monoxide poisoning. They found that it was significantly increased by 90 days after carbon monoxide poisoning. The authors used a cohort crossover design in...
Conclusions If there is a baby with unexplained neurologic symptoms and signs, CO poisoning should be considered in the differential diagnosis. Early diagnosis and treatment prevent complications and sequelaes.
In this study, various biodiesel blends (Chlorella vulgaris, Jatropha curcus, and Calophyllum inophyllum) were investigated for fuel characteristics, and engine performance with exhaust emission compared to diesel. Chlorella vulgaris, Jatropha curcus, and Calophyllum inophyllum biodiesel were synthesized by the acid–base transesterification approach in a microwave reactor and blended with conventional diesel fuel by volume. The fuel blends were denoted as MB10 (90% diesel + 10% microalgae biodiesel), MB20 (80% diesel + 20% microalgae biodiesel), JB10 (90% diesel + 10% jatropha biodiesel), JB20 (80% diesel + 20% j...
Publication date: Available online 30 May 2020Source: The Journal of Chemical ThermodynamicsAuthor(s): Antonin Chapoy, Pezhman Ahmadi, Valdério de Oliveira Cavalcanti Filho, Prashant Jadhawar
Physiological Reports, Volume 8, Issue 11, June 2020.
Publication date: June 2020Source: Annals of Emergency Medicine, Volume 75, Issue 6Author(s): Yifang Xu, Wenchen Li
New J. Chem., 2020, Advance Article DOI: 10.1039/D0NJ01500H, PaperMingming Luo, Zhao Liang, Mingwei Chen, Shaik Gouse Peera, Chao Liu, Hui Yang, Xiaopeng Qi, Juan Liu, Tongxiang Liang CO oxidation on MnC3 and MnC4 has fast kinetics and a low energy barrier. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
CONCLUSION: Lung function abnormalities, psychological impairment and reduced exercise capacity were common in SARS and MERS survivors. Clinicians should anticipate and investigate similar long-term outcomes in COVID-19 survivors. PMID: 32449782 [PubMed - as supplied by publisher]
This study examined the characteristics of particulate matter (PM), nitrogen oxides (NOx), carbon monoxide (CO), and hydrocarbons in diesel locomotive engine exhaust. Emission concentrations were evaluated and compared with the existing regulations. In the case of PM and NOx, emission concentrations increased as engine output increased. High concentrations of CO were detected at engine start and acceleration, while hydrocarbons showed weakly increased concentrations regardless of engine power. Based on fuel consumption and engine power, the emission patterns of PM and gaseous substances observed in this study were slightly...
The recently published Global Lung Function Initiative (GLI) carbon monoxide transfer factor (TLCO) reference equations provide an opportunity to adopt a current, all-age, widely applicable reference set. The aim of this study was to document the effect of changing to GLI from commonly utilised reference equations on the interpretation of TLCO results. 33 863 TLCO results (48% female, 88% Caucasian, n=930 aged