Treatment resistant opioid use disorder (TROUD): Definition, rationale, and recommendations

The opioid overdose epidemic kills about 130 people a day in the United States and it is estimated that there are about 2.1 million people who suffer from an opioid use disorder (OUD). Academic neuroscientists, psychiatrists and the National Institute of Drug Abuse have spent the last forty-years establishing the foundation of addiction as a brain disorder. It is now clear that extended opioid use causes multiple important and at times, irreversible changes to the brain, especially to its dopamine and opioid systems.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Review Article Source Type: research

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COVID-19: Courtesy of NIAID The precarious intersection of the COVID-19 national health emergency and the concurrent epidemic of drug overdose deaths is outlined in the Annals of Internal Medicine this week by Dr. Nora D. Volkow, director of the National Institute on Drug Abuse (NIDA), part...
Source: NIDA News - Category: Addiction Tags: Addiction Science, Health and Medical Professionals, Methamphetamine, NIDAMED News, Opioids, Researchers, Tobacco Source Type: news
The overprescribing of opioid pain relievers (OPR) has led to a significant increase in opioid addiction and overdose. A cornerstone of combating the opioid epidemic is the development of peri-operative evidence based guidelines to standardize OPR prescribing practices and of opioid sparing Enhanced Recovery After Surgery (ERAS) protocols. ERAS has been found to reduce the volume of OPR prescribed while improving outcomes and overall patient satisfaction in adult gynecologic and multiple pediatric surgical specialties.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
With the rise of the opioid epidemic, stories of addiction and its casualties feature prominently in the media with unprecedented frequency. According to the CDC, in 2016, more than 60,000 individuals died of drug overdose. Though we would like to imagine that this modern-day plague has left youths untouched, research suggests otherwise. According to the authors of Brief Interventions for Adolescent Alcohol and Substance Use, “when considering substance use etiology and interventions, one obvious reason to focus on adolescence is because that’s where the drugs are” (p 17).
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Book forum Source Type: research
More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain, contributing to a significant and alarming epidemic of opioid overdose deaths and addiction. Innovative scientific solutions to develop non-opioid, non-addictive alternative treatment options are thus urgently needed. One of the goals of the Helping to End Addiction Long-term (HEAL) Initiative is to accelerate the discovery and preclinical development of new medications and devices to...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain, contributing to a significant and alarming epidemic of opioid overdose deaths and addiction. Innovative scientific solutions to develop non-opioid, non-addictive alternative treatment options are thus urgently needed. One of the goals of the Helping to End Addiction Long-term (HEAL) Initiative is to accelerate the discovery and preclinical development of new medications and devices to...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Conclusions: Fatal opioid overdose accounted for over half a million YLL in Ohio during the 7-year study period. Opioid overdose mortality rose annually. Fentanyl involved overdoses accounted for a growing proportion of excess mortality. Burden was not equally distributed within the state. Two distinct geographical clusters of excess mortality were identified in the northeast and south.
Source: Journal of Addiction Medicine - Category: Addiction Tags: Original Research Source Type: research
New research appearing in the journal Addiction shows that the number of deaths attributed to opioid-related overdoses could be 28 percent higher than reported due to incomplete death records. This discrepancy is more pronounced in several states, including Alabama, Mississippi, Pennsylvania, Louisiana, and Indiana, where the estimated number of deaths more than doubles – obscuring the scope of the opioid crisis and potentially affecting programs and funding intended to confront the epidemic.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news
Authors: Hanna MN, Chambers C, Punyala A, Iqbal A, Singh B, Oruc C, Prakash P, Prajapati Y, Wang Y, Amery Ai Z, Shechter R, Speed TJ, Koch CG, Williams K Abstract The use of opioid analgesics for pain management has increased dramatically over the past decade, with corresponding increases in negative sequelae including overdose and death. Physicians, policymakers, and researchers are focused on finding ways to decrease opioid use and overdose. This crisis calls for a coordinated response that includes the entire healthcare sector. In this work, the authors lay out a blueprint for such a response at the level of the...
Source: Journal of Opioid Management - Category: Addiction Tags: J Opioid Manag Source Type: research
CONCLUSIONS: Given increasing rates of opioid addiction and death, viable solutions are universally needed. Successful intervention measures should be widely shared between military, veteran, and civilian healthcare and public health communities. Increased collaboration between these groups could inculcate successful programs to prevent and decrease opioid use. Results received from recent military and veterans' programs for prescription and electronic medical record (EMR) monitoring and data sharing may also prove useful for civilian healthcare providers and hospital systems. Future evaluations from ongoing federally fund...
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
New largescale study in the American Journal of Preventive Medicine found overprescription of opioids by dentists common, particularly to patients at high risk for substance abuse, and that almost 1/3 of patients received more powerful drugs than neededElsevierIMAGE: In this cross-sectional analysis of 542,958 dental visits by adult patients, between 1 in 4 and 1 in 2 opioid prescriptions exceeded the recommended morphine equivalents and days'supply for...viewmore Credit: Michelle S. Woods Ann Arbor, February 4, 2020 - Dentists are among top prescribers of opioids in the US, however, whether their opioid prescrib...
Source: Dental Technology Blog - Category: Dentistry Source Type: news
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