Treatment resistant opioid use disorder (TROUD): Definition, rationale, and recommendations

The opioid overdose epidemic kills about 130 people a day in the United States and it is estimated that there are about 2.1 million people who suffer from an opioid use disorder (OUD). Academic neuroscientists, psychiatrists and the National Institute of Drug Abuse have spent the last forty-years establishing the foundation of addiction as a brain disorder. It is now clear that extended opioid use causes multiple important and at times, irreversible changes to the brain, especially to its dopamine and opioid systems.

Source: Journal of the Neurological Sciences - February 4, 2020 Category: Neurology Authors: David A. Patterson Silver Wolf, Mark Gold Tags: Review Article Source Type: research