Hepatitis C Virus-associated Lymphoplasmacytic Lymphoma With Waldenstr öm Macroglobulinemia: Response to Direct-acting Antiviral Therapy

Lymphoplasmacytic lymphoma (LPL) with or without Waldenstr öm macroglobulinemia (WM) is a rare lymphoproliferative disorder (LPD) characterized by the presence of monoclonal immunoglobulin M (IgM) paraproteinemia and bone marrow (BM) infiltration by small lymphocytes with plasmacytoid or plasma cell differentiation.1 LPL/WM constitutes less than 5% of all non-Hodgkin lymphomas (NHLs) and 1% to 2% of hematologic malignancies.2 Patients with LPL/WM may be initially asymptomatic (smoldering WM), but over the course of their disease, they may present with fatigue, shortness of breath, anemia, lymphadenopathy (LAD), splenomegaly, and purpura associated wi th cryoglobulinemia.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research