Preclinical toxicological study of prolonged exposure to ketamine as an antidepressant.

CONCLUSIONS: Our data indicate that the alterations observed are minor and due to a predicted mechanism of action, which implies that ketamine is a promising drug for repurposing as an antidepressant.
PMID: 32016837 [PubMed - in process]

Source: Pharmacological Reports - January 31, 2020 Category: Drugs & Pharmacology Authors: Zaccarelli-Magalhães J, Fukushima AR, Moreira N, Manes M, de Abreu GR, Ricci EL, Waziry PAF, Spinosa HS Tags: Pharmacol Rep Source Type: research