A case report of superior mesenteric artery syndrome that developed in a lean type 2 diabetic patient and was associated with rapid body weight loss after sodium ‐glucose cotranspoter‐2 inhibitor administration

AbstractA 58 ‐year‐old female who was diagnosed with type 2 diabetes 20 years earlier had been treated with antidiabetic medicines since she was 40 years old. After sodium‐glucose cotransporter‐2 inhibitors (SGLT2i) administration, her body weight (BW) rapidly decreased from 40 to 30 kg over 3 weeks. She had abdominal symptoms, including nausea, especially after a meal. On admission, physical examinations and laboratory data indicated euglycemic ketoacidosis, dehydration and low insulin secretion levels. Additionally, abdominal contrast computed tomography demonstrated the finding of superior mesen teric artery syndrome. This case urges caution, including rapid excess BW loss and euglycemic ketoacidosis, on the use of SGLT2i for lean diabetic patients.

Source: Journal of Diabetes Investigation - February 6, 2020 Category: Endocrinology Authors: Taro Hirai, Munehiro Kitada, Yoshihiro Hayashi, Itaru Monno, Yuta Takagaki, Keiji Shimada, Yoshio Ogura, Mizue Fujii, Kazunori Konishi, Atsushi Nakagawa, Daisuke Koya Tags: CASE REPORT Source Type: research