Spinal GRPR and NPRA contribute to chronic itch in a murine model of allergic contact dermatitis.

In this study, we investigated the peripheral and spinal mechanisms responsible for prolonged itch in a mouse model of allergic contact dermatitis (ACD) induced by squaric acid dibutylester (SADBE). We found that repeated exposure of mice to SADBE evoked persistent spontaneous scratching and significantly aberrant cutaneous and systemic immune responses lasting for weeks.

Source: Journal of Investigative Dermatology - February 4, 2020 Category: Dermatology Authors: Xueting Liu, De Wang, Yuhuan Wen, Liping Zeng, Yangyang Li, Tianyu Tao, Zhongqiu Zhao, Ailin Tao Tags: Original Article Source Type: research