ATP-P2X7-induced inflammasome activation contributes to melanocyte death and CD8+ T-cell trafficking to the skin in vitiligo

This study presents how extracellular ATP, released from keratinocytes by oxidative stress, affects melanocyte survival in vitiligo skin. H2O2-induced oxidative injury increased ATP release from keratinocytes and skin tissues.

Source: Journal of Investigative Dermatology - February 4, 2020 Category: Dermatology Authors: Yuri Ahn, Jimyung Seo, Eun Jung Lee, Ji Young Kim, Min-Young Park, Shinwon Hwang, Abdurrahman Almurayshid, Beom Jin Lim, Je-Wook Yu, Sang Ho Oh Tags: Original Article Source Type: research