Nm23 ‐H1 inhibits lung cancer bone‐specific metastasis by upregulating miR‐660‐5p targeted SMARCA5

ConclusionNm23 ‐H1 inhibits tumor progression and bone‐specific metastasis of lung cancer by regulating miR‐660‐5p/SMARCA5/RANKL axis, which indicates the related genes may serve as potential targets for the treatment of human lung cancer.Key pointsSignificant findings of the studyHigh expression of nm23 ‐H1 correlated with decreased miRNA‐660‐5p expression. Further, downregulation of miR‐660‐5p significantly suppressed the tumor progression and bone‐specific metastasis of lung cancer cells.What this study addsThis is the first study to show an inverse association between nm23 ‐H1 and miR‐660‐5p, and confirm that nm23‐H1 inhibits tumor progression and bone‐specific metastasis of lung cancer by regulating miR‐660‐5p/SMARCA5/RANKL axis.

Source: Thoracic Cancer - February 6, 2020 Category: Cancer & Oncology Authors: Cheng Ai, Guangzhi Ma, Yunfu Deng, Qiangqiang Zheng, Yingcai Gen, Wen Li, Yang Li, Lingling Zu, Qinghua Zhou Tags: ORIGINAL ARTICLE Source Type: research