The real cost, and longer term implications, of the Wuhan coronavirus

It's too soon to know for sure how the tale of the novel coronavirus will play out,but at this point we have a pretty good idea. A stipulation in both of the scenarios at the linked essay is that yeah, it gets loose into the wild and eventually can show up anywhere in the world. I think that's pretty much definitely going to happen if it hasn't already.Scenario number 1, and most likely, in my view, it will just be one more virus that causes what amounts to a common cold and in a few people who are otherwise debilitated goes on to be complicated by pneumonia. In that case, for a year or two it will circulate as a novel virus to which no-one is immune and there will be a fairly high incidence -- although most people who are exposed will have no symptoms, or very mild symptoms. Then things will settle down and it will hardly be noticeable. One more common cold virus won't make a big difference, there are already dozens of them. Note that the most likely evolutionary trajectory for any endemic virus is that it becomes less virulent over time, because people who are lying on their couch all day aren't likely to transmit it.Scenario number 2 is that it's a bit more virulent, like influenza, and also tends to recur seasonally. having one more influenza virus to contend with is definitely not better than a poke in the eye with a sharp stick, however since this class of virus, unlike influenza, has a very low mutation rate, it should be possible to make an effective vaccine that's go...
Source: Stayin' Alive - Category: American Health Source Type: blogs

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Authors: Zhou DN, Ye CS, Yang QQ, Deng YF Abstract Non-coding RNAs (ncRNAs) regulate numerous genes and influence the progression of various human diseases, including cancer. The role of regulatory ncRNAs implicated in nasopharyngeal carcinoma (NPC), as well as their target genes, remains unclear. The present study aimed to investigate specific long non-coding (lnc)RNAs, circular RNAs (circRNAs) and mRNAs associated with the molecular pathogenesis of NPC, and to predict the underlying target genes of specific lncRNAs and circRNAs. The expression levels of lncRNAs, circRNAs and mRNAs in NPC and chronic nasopharyngit...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, the present study revealed that the upregulation of RBM47 accelerated the malignant progression of NSCLC, indicating that RBM47 may be a potential biomarker for NSCLC progression and a therapeutic target for NSCLC. PMID: 32218862 [PubMed - as supplied by publisher]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Kang Y, Cui Y, Tan M Abstract Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck that is prevalent in China. The present study investigated the molecular mechanisms of microRNA-212 (miR-212) and E74-like factor 3 (ELF3) in NPC cell lines and tissues. Using reverse transcription-quantitative PCR, the present study identified that miR-212 expression was downregulated in NPC cell lines and tissues. Furthermore, an elevated expression level of miR-212 was revealed to inhibit NPC cell proliferation, as determined using a cell counting kit-8 assay in vitro. ELF3 was identified as a d...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Wang QS, Wei SR, Xiao HL Abstract Lung cancer is the most common cause of cancer-associated mortality in China with 85% of patients having non-small cell lung cancer (NSCLC). Identifying NSCLC driver genes and prognostic markers is critical to reducing these numbers. The studies of retinoblastoma binding protein 6 (RBBP6) performed on NSCLC is limited. The present study aimed to investigate the molecular function and the prognostic potential of RBBP6 in NSCLC using the A549 cell line and patient samples, respectively. The functional effect on cancer cell proliferation and prognostic value of RBBP6 were exa...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, CCL14 is an independent prognostic factor for EOC and upregulation of CCL14 is associated with a more favorable prognosis in patients with EOC. PMID: 32218842 [PubMed - as supplied by publisher]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: Available online 29 March 2020Source: LWTAuthor(s): Biao Suo, Wenjing Nie, Yuexia Wang, Jingyi Ma, Xiaolong Xing, Zhongmin Huang, Chao Xu, Zhen Li, Zhilu Ai
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
[Nation] The number of coronavirus cases in Kenya has risen to 42 after four more cases were confirmed on Sunday.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Nearly 900 positive cases of COVID-19 have been reported in North Texas, including 13 deaths. Two North Texas U.S. Postal workers were a part of that number after they tested positive for the disease as well, USPS officials confirmed Saturday. One of the employees works at Huffhines Park Post Office while the other is at the Dallas Network Distribution Center. "We are in the process of reaching out to the local public health offices and will follow the guidance they provide," USPS officials said…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Authors: Chen YQ, Zhao SP, Ye HJ Abstract Backgroud: We investigated the lipid-lowering efficacy and safety of coenzyme A (CoA) versus fenofibrate in Chinese patients with moderate dyslipidemia.Methods: A total of 417 subjects (aged 18-75 years) diagnosed with moderate dyslipidemia (triglyceride, 2.3-6.5 mmol/L) from 13 large cardiovascular centers in China were recruited and randomly divided into a fenofibrate group (n = 207), which received 200mg of fenofibrate orally once daily, and a CoA group (n = 210), which received 400mg of CoA orally once a day. Blood lipoproteins, liver ...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Publication date: Available online 28 March 2020Source: Chinese Chemical LettersAuthor(s): Zhijie Fang, Zhe Su, Wenjing Qin, Hao Li, Bing Fang, Wei Du, Qiong Wu, Bo Peng, Peng Li, Haidong Yu, Lin Li, Wei Huang
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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