News Beyond Our Pages

Maun et al (Cell 2019;179:417-31.e19. doi: https://doi.org/10.1016/j.cell.2019.09.009) discovered that mast cell –derived tryptase levels correlate with asthma severity independent of the degree of type 2 inflammation present. Furthermore, genetic alleles that increase the activity of tryptase decrease response to treatment with the IgE-neutralizing antibody omalizumab. In response to these findings, the aut hors generated a noncompetitive allosteric inhibitor of tryptase, which potently inhibited airway tryptase activity and reduced anaphylaxis in experimental animal models.

https://www.jacionline.org/article/S0091-6749(19)32597-7/abstract?rss=yes

Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet Tags: News beyond our pages Source Type: research