Iron trafficking in patients with Indian Post kala-azar dermal leishmaniasis

Conclusions/SignificanceIn monocytes/macrophages of PKDL cases, enhancement of the iron influx gateways (TfR, CD163, DMT-1 and Lcn-2) possibly accounted for the enhanced LIP. However, enhancement of the iron exporters (NRAMP-1 and Fpn-1) defied the classical Ferritinlow/Ferroportinhigh phenotype of alternatively activated macrophages. The creation of such a pro-parasitic environment suggests incorporation of chemotherapeutic strategies wherein the availability of iron to the parasite can be restricted.

Source: PLoS Neglected Tropical Diseases - February 4, 2020 Category: Tropical Medicine Authors: Aishwarya Dighal Source Type: research