Real-time imaging of infarction deterioration after ischemic stroke in rats using electrical impedance tomography

This study investigated the feasibility of electrical impedance tomography (EIT) for
monitoring the deterioration of ischemic lesion after the onset of stroke. Approach : Fifteen rats
were randomly distributed into two groups: rats operated to establish a right middle cerebral artery
occlusion (MCAO) ( n   =  10), and sham-operated rats ( n   =  5). Then, the operated rats were kept
2  h under anesthesia for EIT monitoring. Subsequently, descriptive statistical analysis was
performed on whole-brain resistivity changes, and repeated-measures analysis of variance (ANOVA) on
the average resistivity variation index. Additionally, pathological examinations were performed
after 6  h of infarction. Main results : The results obtained showed that ischemic damage developed
in the right corpus striatum of the rats with MCAO, whereas the brains of the sham group showed no
anomalies. The descriptive statistical analysis revealed that the whole-brain re...

Source: Physiological Measurement - February 4, 2020 Category: Physiology Authors: Lu Cao, Haoting Li, Danchen Fu, Xuechao Liu, Hang Ma, Canhua Xu, Xiuzhen Dong, Bin Yang and Feng Fu Source Type: research