Grayanane diterpenoids from the leaves of Rhododendron dauricum

Publication date: April 2020Source: Biochemical Systematics and Ecology, Volume 89Author(s): Xiang Peng, Hanqi Zhang, Xinghua Yuan, Zibo Chen, Jinbo Gao, Yang Teng, Guangmin YaoAbstractPhytochemical investigations on the leaves of Rhododendron dauricum L. (Ericaceae) resulted in the isolation of thirteen known grayanane diterpenoids (1–13). Their structures were determined by spectroscopic data analysis and comparison with the literature. The structure and absolute configuration of grayanotoxin VI (1) was determined by single-crystal X-ray diffraction analysis for the first time. This is the first time to report the isolation of grayanane diterpenoids 1–10, 12, and 13 from Rhododendron dauricum. Grayanotoxin VI (1) was isolated from the genus of Rhododendron for the first time. The chemotaxonomic significance of grayanane diterpenoids (1–13) was discussed.Graphical abstractThirteen grayanane diterpenoids (1–13) were isolated from the leaves of Rhododendron dauricum L. (Ericaceae), and twelve grayanane diterpenoids 1–10, 12, and 13 were isolated from R. dauricum for the first time. This is the first report of the crystal structure of grayanotoxin VI (1), which was isolated from the Rhododendron genus for the first time. The chemotaxonomic significance of the isolated grayanane diterpenoids was discussed.

Source: Biochemical Systematics and Ecology - February 5, 2020 Category: Biochemistry Source Type: research