New avenues for therapeutic discovery against West Nile virus

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Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research

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Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
by Ilaria Caracciolo, Erick Mora Cardenas, Chiara Aloise, Tea Carletti, Ludovica Segat, Maria Sole Burali, Alexsia Chiarvesio, Vivianna Totis, Tatjana Av šič–Županc, Eloise Mastrangelo, Giuseppe Manfroni, Pierlanfranco D’Agaro, Alessandro Marcello Surveillance of Usutu virus is crucial to prevent future outbreaks both in Europe and in other countries currently naïve to the infection, such as the Americas. This goal remains difficult to achieve, notably because of the lack of large-scale cohort studies and the absence of commercially availa ble diagnostic reagents for USUV. This work started with ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Around the world, more than 40 teams are working on a vaccine for Covid-19. We followed one doctor in the most urgent quest of his life. By Samanth SubramanianCoronavirus – latest updatesSee all our coronavirus coverageOf the dozens of places where a coronavirus vaccine might be born, one is DIOSynVax, a small company started by a Canadian pathologist named Jonathan Heeney. In ordinary times, I ’d have visited Heeney in his office, in a stately red-brick building in Cambridge. I’d have met his team and his Aria III cytometer, which looks like as if might brew a strong, space-age espresso but which, in fac...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Vaccines and immunisation Infectious diseases Medical research Microbiology Science World news Health Source Type: news
Publication date: Available online 24 March 2020Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Abdelfattah Selim, Ahmed Radwan, Faysal Hamouda
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
by Agathe M. G. Colmant, Helle Bielefeldt-Ohmann, Laura J. Vet, Caitlin A. O ’Brien, Richard A. Bowen, Airn E. Hartwig, Steven Davis, Thisun B. H. Piyasena, Gervais Habarugira, Jessica J. Harrison, Jody Hobson-Peters, Roy A. Hall Flaviviruses such as yellow fever, dengue or Zika viruses are responsible for significant human and veterinary diseases worldwide. These viruses contain an RNA genome, prone to mutations, which enhances their potential to emerge as pathogens. Bamaga virus (BgV) is a mosquito-borne flavivirus in th e yellow fever virus group that we have previously shown to be host-restricted in vertebrates ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
In conclusion, benzavir-2 was a potent inhibitor of flavivirus infection, which supported the broad-spectrum antiviral activity of benzavir-2.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
ie Lecollinet Cécile Beck The geographical distribution and impact on animal and human health of both West Nile and Usutu viruses, two flaviviruses of the Japanese encephalitis complex, have been increasing during the past two decades. Both viruses circulate in Europe and Africa within a natural cycle between wild birds and mosquitoes, mainly from the Culex genus. We retrospectively analyzed sera from domestic and wild birds sampled in 2008 in two wetlands, namely the Inner Niger Delta, Mali, and the Lake Alaotra area, Madagascar. Sera were first tested using a commercial ID Screen West Nile Competition Multi-...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Authors: Di Pierro F, Bertuccioli A, Cavecchia I Abstract The outbreak of SARS-CoV-2 disease (COVID-19) is currently, March 2020, affecting more than 100000 people worldwide and, according to the WHO (World Health Organization), a pandemic is shortly expected. The virus infects the lower respiratory tract and causes severe pneumonia and mortality in approximately 10% and 3-5%, respectively, of cases, mainly among the elderly and/or people affected by other diseases. AHCC is an α-glucan-based standardized mushroom extract that has been extensively investigated as an immunostimulant both in animals and/or in hu...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
CONCLUSIONS: We recommend implementing a temporary blood donor deferral following a JEV vaccination, if screening utilizes a WNV assay with the capability of detecting other members of the JE serocomplex. PMID: 32154927 [PubMed - as supplied by publisher]
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research
by Yujiao Zhao, Matthew Amodio, Brent Vander Wyk, Bram Gerritsen, Mahesh M. Kumar, David van Dijk, Kevin Moon, Xiaomei Wang, Anna Malawista, Monique M. Richards, Megan E. Cahill, Anita Desai, Jayasree Sivadasan, Manjunatha M. Venkataswamy, Vasanthapuram Ravi, Erol Fikrig, Priti Kumar, Steven H. Kleinstein, Smita Krishnaswamy, Ruth R. Montgomery The genus Flavivirus contains many mosquito-borne human pathogens of global epidemiological importance such as dengue virus, West Nile virus, and Zika virus, which has recently emerged at epidemic levels. Infections with these viruses result in divergent clinical outcomes ranging f...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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